 Home > Encyclopedia > Anecortave

Anecortave

Anecortave structure

CAS No:
7753-60-8
Formula:
C23H30O5
Chemical Name:
Anecortave
Synonyms:
Pregna-4,9(11)-diene-3,20-dione,21-(acetyloxy)-17-hydroxy-;Pregna-4,9(11)-diene-3,20-dione,17,21-dihydroxy-,21-acetate;21-(Acetyloxy)-17-hydroxypregna-4,9(11)-diene-3,20-dione;21-Acetoxypregna-4,9(11)-dien-17α-ol-3,20-dione;Al 3789;Anecortave acetate;Anecortave;NSC 15475;NSC 24345;Retaane;2-((10S,13S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;2488831-60-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Anecortave acetate is an organic molecular entity.|Anecortave acetate (Retaane) is an analog of cortisol acetate; among the modifications to the steroid are the removal of the 11ß hydroxyl OH group and an addition of a 21-acetate group. As a result of these modifications, anecortave acetate lacks the typical antiinflammatory and immunosuppressive properties of glucocorticoids.Alcon Inc. is developing and marketing Retaane.

Anecortave Basic Attributes

Molecular Weight：

386.48

Exact Mass：

386.48

EC Number：

231-812-5

UNII：

Y0PC411K4T

NSC Number：

24345|15475

DSSTox ID：

DTXSID5046805

Characteristics

PSA：

80.7 Å²

Density：

1.23±0.1 g/cm3

Melting Point：

231.5-234.5 °C @ Solvent: Chloroform, Diethyl ether

Boiling Point：

551.8±50.0 °C(Predicted)

PKA：

12.47±0.60

Drug Information

Drug Indication：

Investigated for use/treatment in glaucoma and macular degeneration.

Mechanism of Action：

Anecortave acetate functions as an antiangiogenic agent, inhibiting blood vessel growth by decreasing extracellular protease expression and inhibiting endothelial cell migration. Its angiostatic activity does not seem to be mediated through any of the commonly known pharmacological receptors. (Ophthalmology 2004;111:2316-7) RETAANE blocks signals from multiple growth factors because it acts downstream and independent of the initiating angiogenic stimuli and inhibits angiogenesis subsequent to the angiogenic stimulation.

MeSH Entry Terms：

4,9(11)-pregnadien-17alpha,21-diol-3,20-dione-21-acetate

Anecortave Use and Manufacturing

As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.

Computed Properties

Molecular Weight:386.5
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:386.20932405
Monoisotopic Mass:386.20932405
Topological Polar Surface Area:80.7
Heavy Atom Count:28
Complexity:808
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Anecortave

Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

Anecortave Acetate

CAS No.: 7753-60-8

Content: 99%

Inquiry
Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% Anecortave acetate Medical Grade CAS7753-60-8

CAS No.: 7753-60-8

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry