5-O-Desmethyl donepezil
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5-O-Desmethyl donepezil
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CAS No:
120013-57-2
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Formula:
C23H27NO3
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Chemical Name:
5-O-Desmethyl donepezil
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Synonyms:
1H-Inden-1-one,2,3-dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-;2,3-Dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one;1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methyl]piperidine;5-O-Desmethyl donepezil;2-[(1-Benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one;147451-82-9
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CAS No:
Description
5-O-desmethyldonepezil is a member of the class of piperidines that is donepezil in which the 5-methoxy group has been demethylated to the corresponding hydroxy derivative. It is metabolite of donepezil, a drug used in the treatment of dementia. It has a role as a drug metabolite. It is a member of piperidines, a cyclic ketone, an aromatic ether and a member of guaiacols.
Characteristics
49.77000
3.99600
1.191g/cm3
170-171 °C (decomp)
545.301ºC at 760 mmHg
283.588ºC
1.604
0mmHg at 25°C
Drug Information
5-O-Desmethyl Donepezil has known human metabolites that include (2S,3S,4S,5R)-6-[[2-[(1-benzylpiperidin-4-yl)methyl]-6-methoxy-1-oxo-2,3-dihydroinden-5-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid.
Computed Properties
Molecular Weight:365.5
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:365.19909372
Monoisotopic Mass:365.19909372
Topological Polar Surface Area:49.8
Heavy Atom Count:27
Complexity:496
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
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Dehydrodeoxy Donepezil (Donepezil Impurity)
120013-45-8
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Donepezil hydrochloride
120011-70-3
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Donepezil
120014-06-4
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1-Deoxo-1,2-dehydro-N-desbenzyl-N-tert-butyloxycarbonyl Donepezil Formula
1346600-41-6
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