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Donepezil hydrochloride

Donepezil hydrochloride structure

CAS No:
120011-70-3
Formula:
C24H29NO3.ClH
Chemical Name:
Donepezil hydrochloride
Synonyms:
1H-Inden-1-one,2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-,hydrochloride (1:1);1H-Inden-1-one,2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-,hydrochloride;E 2020;E 2020 (pharmaceutical);BNAG;Donepezil hydrochloride;Aricept;Aricept D;Dopezil;Dorent;Donep;1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride;Aricept ODT;142057-77-0
Categories:
Biochemical Engineering > Inhibitors

Description

Donepezil hydrochloride is known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride[1]. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in ace

An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.

Donepezil hydrochloride Basic Attributes

Molecular Weight：

415.95300

Exact Mass：

415.19100

NSC Number：

758882|737535

DSSTox ID：

DTXSID0046698

ATC Code：

N06D|N06DA52

HScode：

2933399090

Characteristics

PSA：

38.77000

XLogP3：

5.10100

Appearance：

white to off-white crystalline solid

Melting Point：

211-212 °C

Boiling Point：

527.9ºC at 760 mmHg

Flash Point：

273.1ºC

Water Solubility：

In water, 2.93 mg/L at 25 deg C (est)

Storage Conditions：

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

Vapor Pressure：

3.11E-11mmHg at 25°C

Collision Cross Section：

196.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN 2811

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P310, P305+P351+P338, P321, P330, P337+P313, P405, P501

Hazard Statements：

H300

GHS Classification：

|Danger|H301 (90.95%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P305+P351+P338, P321, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 210 companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Treatment of Alzheimers disease

MeSH：

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)|Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

MeSH Entry Terms：

1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride

Donepezil hydrochloride Use and Manufacturing

Uses

1. A nootropic. An inhibitor of acetylcholinesterase
2. A labelled nootropic. An inhibitor of acetylcholinesterase.
3. Antialzheimer
4. Labeled Donepezil, intended for use as an internal standard for the quantification of Donepezilby GC- or LC-mass spectrometry.

Use Classification：

Human drugs -> Acrescent -> EMA Drug Category|Human drugs -> Balaxur -> EMA Drug Category|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:416.0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:415.1914215
Monoisotopic Mass:415.1914215
Topological Polar Surface Area:38.8
Heavy Atom Count:29
Complexity:510
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific pharmacological information is provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Donepezil Hydrochloride Capsules
Ingredients	Donepezil hydrochloride chemical name: l-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methyl]piperidine hydrochloride.
Specifications	5mg
Manufacturer	YANGTZE River Pharmaceutical Group Shanghai HAI-NI Pharmaceutical Co., Ltd.

Donepezil hydrochloride orally disintegrating tablets
Specifications	5mg
Manufacturer	Sichuan Sunnyhope Pharmaceutical Co., Ltd.

Donepezil Hydrochloride Tablets
Ingredients	Donepezil hydrochloride. Chemical name: () 2,3-dihydro-5,6-dimethoxy-2-{[(1-phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one hydrochloride.
Indication	Phenytoin sodium, carbamazepine, dexamethasone, rifampicin, and phenobarbital, inducers of CYP3A4 and CYP2D6 isoenzymes, can increase the clearance rate of this product. Ketoconazole and quinidine, inhibitors of CYP3A4 and CYP2D6 isoenzymes, inhibit the metabolism of this product. This product has not been found to interfere with the metabolism of theophylline, cimetidine, warfarin, and digoxin. 4. This product may affect drugs with anticholinergic activity.
Specifications	5mg
Manufacturer	Shaanxi ARK Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Jining Shenzhou Pharmaceutical Co., Ltd.

China
Active
MEGAFINE PHARMA P LTD

United States
Active
APITORIA PHARMA PRIVATE LTD

United States
Active

See More Registered Holders

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