Tetrahydrouridine
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Tetrahydrouridine
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CAS No:
18771-50-1
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Formula:
C9H16N2O6
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Chemical Name:
Tetrahydrouridine
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Synonyms:
Uridine,3,4,5,6-tetrahydro-;2(1H)-Pyrimidinone,tetrahydro-4-hydroxy-1-β-D-ribofuranosyl-;3,4,5,6-Tetrahydrouridine;1-(β-D-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone;Tetrahydrouridine;NSC 112907;68060-67-3
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CAS No:
Description
Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.|An inhibitor of nucleotide metabolism.
Characteristics
130.33000
-2.73000
1.622g/cm3
668.6ºC at 760mmHg
358.2ºC
1.654
-20ºC
0.65mmHg at 25°C
Drug Information
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Antimetabolites.)
NSC 112907
Computed Properties
Molecular Weight:248.23
XLogP3:-2.4
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:248.10083623
Monoisotopic Mass:248.10083623
Topological Polar Surface Area:123
Heavy Atom Count:17
Complexity:301
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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