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1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine

1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine structure

CAS No:
76778-22-8
Formula:
C28H34N2O
Chemical Name:
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine
Synonyms:
Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine;GBR 12935;GBR 1293;1-(2-Benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine

Description

1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine is an N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes). It has a role as a dopamine uptake inhibitor. It is a N-alkylpiperazine, an ether and a tertiary amino compound. It is a conjugate base of a 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazinediium(2+).

1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine Basic Attributes

Molecular Weight：

530.65500

Exact Mass：

414.58

UNII：

9J9974WIBA

DSSTox ID：

DTXSID2043743

HScode：

2933599090

Characteristics

PSA：

90.31000

XLogP3：

4.63060

Density：

1.067g/cm3

Boiling Point：

546ºC

Flash Point：

143.9ºC

Refractive Index：

1.576

Storage Conditions：

Desiccate at -20ºC

Drug Information

MeSH：

Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake. (See all compounds classified as Dopamine Uptake Inhibitors.)

MeSH Entry Terms：

1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine

Computed Properties

Molecular Weight:414.6
XLogP3:5.4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:10
Exact Mass:414.267113712
Monoisotopic Mass:414.267113712
Topological Polar Surface Area:15.7
Heavy Atom Count:31
Complexity:440
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties

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