Oxyphencyclimine
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Oxyphencyclimine
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CAS No:
125-53-1
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Formula:
C20H28N2O3
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Chemical Name:
Oxyphencyclimine
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Synonyms:
Benzeneacetic acid,α-cyclohexyl-α-hydroxy-,(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester;Cyclohexaneglycolic acid,α-phenyl-,(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester;2-Pyrimidinemethanol,1,4,5,6-tetrahydro-1-methyl-,α-phenylcyclohexaneglycolate (ester);1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinemethanol α-phenylcyclohexaneglycolate (ester);Oxyphencyclimine;(±)-Oxyphencyclimine;Caridan;Antulcus;Zamanil;Naridan;88245-08-3
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CAS No:
Description
Solid
Oxyphencyclimine is a monocarboxylic acid.|Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.
Oxyphencyclimine Basic Attributes
344.44800
344.45
204-743-3
DTXSID4023410
A - Alimentary tract and metabolism
Drug Information
For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
Oxyphencyclimine is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Oxyphencyclimine is an antimuscarinic, anticholinergic drug.
Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
oxyphencyclimine
Computed Properties
Molecular Weight:344.4
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:344.20999276
Monoisotopic Mass:344.20999276
Topological Polar Surface Area:62.1
Heavy Atom Count:25
Complexity:481
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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