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Oxyphencyclimine hydrochloride

Oxyphencyclimine hydrochloride structure

CAS No:
125-52-0
Formula:
C20H28N2O3.ClH
Chemical Name:
Oxyphencyclimine hydrochloride
Synonyms:
Benzeneacetic acid,α-cyclohexyl-α-hydroxy-,(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester,hydrochloride (1:1);Cyclohexaneglycolic acid,α-phenyl-,(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester monohydrochloride;Benzeneacetic acid,α-cyclohexyl-α-hydroxy-,(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester,monohydrochloride;Daricon;Dominil;(1-Methyl-1,4,5,6-tetrahydro-2-pyrimidyl)methyl α-cyclohexyl-α-phenylglycolate hydrochloride;Oxyphencyclimine hydrochloride;Setrol;Ulcociclinina;Oximin;Vio-Thene;Daricol;S 1-1236;Enterex;Syklifen;(±)-Oxyphencyclimine hydrochloride;NSC 528449;(1-Methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride;108643-63-6;21609-10-9
Categories:
Analytical Chemistry > Standard

Description

Oxyphencycliminehydrochloride, 1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl -phenylcyclohexaneglycolate monohydrochloride(Daricon, Vistrax), was introduced in 1958 and promoted asa peripheral anticholinergic–antisecretory agent, with little orno curare-like activity and little or no ganglionic blocking activity.These activities are probably absent because of the tertiarycharacter of the molecule. This activity is in contrastwith that of compounds that couple antimuscarinic actionwith gangli

Oxyphencyclimine hydrochloride is a member of pyrimidines.

Oxyphencyclimine hydrochloride Basic Attributes

Molecular Weight：

380.91

Exact Mass：

380.18700

EC Number：

204-742-8

NSC Number：

758648|528449

DSSTox ID：

DTXSID6045909

Characteristics

PSA：

62.1

XLogP3：

2.90720

Density：

1.18 g/cm3

Melting Point：

231-232 °C (decomp)

Boiling Point：

528.2ºC at 760 mmHg

Flash Point：

273.2ºC

Refractive Index：

1.587

Water Solubility：

>57.1 [ug/mL]

Toxicity：

LD50 oral in rat: 1370mg/kg

Collision Cross Section：

183.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

hazard class code：

20/21/22

safety instructions：

RTECS Number：

GV3030000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

oxyphencyclimine

Oxyphencyclimine hydrochloride Use and Manufacturing

Uses

Oxyphencyclimine hydrochloride is suggested for usein peptic ulcer, pylorospasm, and functional bowel syndrome.It is contraindicated, as are other anticholinergics,in patients with prostatic hypertrophy and glaucoma.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:380.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:380.1866705
Monoisotopic Mass:380.1866705
Topological Polar Surface Area:62.1
Heavy Atom Count:26
Complexity:481
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Inhibit parasympathetic nerves, relax gastric smooth muscle activity, inhibit gastric acid secretion, relieve spasms and relieve pain

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Hydroxyphenoxybenzylamine Hydrochloride Tablets
Ingredients	This product is a compound preparation, and its components are as follows: Oxyphencyclimine HCl 5mg Simethicone 40mg Vitamin U ethylmethionine Sulfonium Chloride (Vitamin U) 20mg Mag.Trisilicate
Indication	The ingredient hydroxybenzylamine hydrochloride in this product will enhance the anticholinergic effect of antihistamines, and the alkaline drugs aluminum and magnesium may also reduce the absorption of tetracycline.
Specifications	Each tablet contains: 5 mg of hydroxybenzylamine hydrochloride, 20 mg of vitamin U, 275 mg of magnesium trisilicate, 200 mg of aluminum hydroxide gel, and 40 mg of dimethicone.

Compound Hydroxyphenoxybenzylamine Hydrochloride Tablets
Ingredients	This product is a compound preparation, and its components are as follows: Oxyphencyclimine HCl 5mg Simethicone 40mg Vitamin U ethylmethionine Sulfonium Chloride (Vitamin U) 20mg Mag.Trisilicate
Indication	The ingredient hydroxybenzylamine hydrochloride in this product will enhance the anticholinergic effect of antihistamines, and the alkaline drugs aluminum and magnesium may also reduce the absorption of tetracycline.
Specifications	Hydroxybenzylamine hydrochloride 5 mg, dimethicone 40 mg, vitamin U 20 mg, magnesium trisilicate 275 mg, aluminum hydroxide gel 200 mg

Recommended Suppliers of Oxyphencyclimine hydrochloride

Shandong Airuike Chemical Co., Ltd. Contact Supplier

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oxyphencyclimine hydrochloride 125-52-0

CAS No.: 125-52-0

Grade: Chemical Grade

Content: 99%

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Guide of Oxyphencyclimine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Latest News
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Oxyphencyclimine hydrochloride

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