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Tepoxalin

Tepoxalin structure

CAS No:
103475-41-8
Formula:
C20H20ClN3O3
Chemical Name:
Tepoxalin
Synonyms:
1H-Pyrazole-3-propanamide,5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-;5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide;Tepoxalin;ORF 20485;RWJ 20485;Zubrin
Categories:
Active Pharmaceutical Ingredients > Veterinary Raw Materials

Description

Tepoxalin is a hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an apoptosis inhibitor, a lipoxygenase inhibitor and an immunomodulator. It is a member of pyrazoles, an aromatic ether, a hydroxamic acid and a member of monochlorobenzenes.|Tepoxalin is a nonsteroidal anti-inflammatory drug approved for veterinary use in the United States and many other countries. It is primarily used to reduce inflammation and relief of pain caused by musculoskeletal disorders such as hip dysplasia and arthritis.

Tepoxalin Basic Attributes

Molecular Weight：

385.84400

Exact Mass：

385.84

UNII：

TZ4OX61974

DSSTox ID：

DTXSID1057610

ATC Code：

QM01AE92

Characteristics

PSA：

67.59000

XLogP3：

3.98150

Density：

1.26g/cm3

Melting Point：

125-126 °C

Boiling Point：

573ºC

Flash Point：

300.3ºC

Refractive Index：

1.61

Vapor Pressure：

5.72E-14mmHg at 25°C

Drug Information

Drug Indication：

Reduction of inflammation and relief of pain caused by acute and chronic musculoskeletal disorders.

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

MeSH Entry Terms：

5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide

Tepoxalin Use and Manufacturing

Use Classification：

Veterinary drugs -> Zubrin -> EMA Drug Category|Musculo-skeletal system -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:385.8
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:385.1193192
Monoisotopic Mass:385.1193192
Topological Polar Surface Area:67.6
Heavy Atom Count:27
Complexity:479
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Tepoxalin

CAS No.: 103475-41-8

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