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Home > Encyclopedia > (-)-Pyridoxatin

(-)-Pyridoxatin

(-)-Pyridoxatin structure

(-)-Pyridoxatin 

structure
  • CAS No:

    135529-30-5

  • Formula:

    C15H21NO3

  • Chemical Name:

    (-)-Pyridoxatin

  • Synonyms:

    2(1H)-Pyridinone,3-[(1R,2S,4R,6S)-2-ethenyl-4,6-dimethylcyclohexyl]-1,4-dihydroxy-;2(1H)-Pyridinone,3-(2-ethenyl-4,6-dimethylcyclohexyl)-1,4-dihydroxy-,(1α,2β,4β,6β)-(-)-;3-[(1R,2S,4R,6S)-2-Ethenyl-4,6-dimethylcyclohexyl]-1,4-dihydroxy-2(1H)-pyridinone;Pyridoxatin;Acremonium BX 86 factor;BX 86;Pyridoxatine;(-)-Pyridoxatin;N-Hydroxytolypyridone B

Description

Pyridoxatin is a member of the class of dihydroxypyridines that is 1,4-dihydroxypyridin-2-one carrying an additional 6-ethenyl-2,4-dimethylcyclohexyl substituent at position 3. Pyridoxatin is a MMP-2 (Gelatinase A) inhibitor with antibiotic and anticancer properties. Also indicated to be a lipid peroxidation and DNA synthesis inhibitor as well as a free radical scavenger. It has a role as a fungal metabolite, an antimicrobial agent, an antineoplastic agent, a DNA synthesis inhibitor, a radical scavenger and an EC 3.4.24.24 (gelatinase A) inhibitor. It is a pyridone, a dihydroxypyridine and an olefinic compound.

(-)-Pyridoxatin Basic Attributes

263.33200

263.33

DTXSID70159458

Characteristics

62.46000

2.74300

1.245g/cm3

393.5ºC

191.8ºC

1.627

7.99E-08mmHg at 25°C

Drug Information

pyridoxatin

Computed Properties

Molecular Weight:263.33
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:263.15214353
Monoisotopic Mass:263.15214353
Topological Polar Surface Area:60.8
Heavy Atom Count:19
Complexity:452
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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