N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine
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![N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/fe521c22b5cc493abf13cae5896d39b9.png "N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine")
N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine
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CAS No:
119422-08-1
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Formula:
C16H38N4
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Chemical Name:
N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine
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Synonyms:
1,4-Butanediamine,N1,N4-bis[4-(ethylamino)butyl]-;1,4-Butanediamine,N,N′-bis[4-(ethylamino)butyl]-;N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine;N1,N14-Diethylhomospermine;N1,N14-Bis(ethyl)homospermine;1,14-Bis(ethylamino)-5,10-diazatetradecane;DE 444;BE 4-4-4;BEHSPM;SL 11156;BE 444;1,4-Butanediamine N1,N4-bis[4-(ethylamino)butyl]-
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CAS No:
Description
Diethylhomospermine has been used in trials studying the treatment of Diarrhea and HIV Infections.|Diethylhomospermine is a polyamine analogue with antiproliferative and potential anti-diarrheal activities. Diethylhomospermine (DEHSPM) antagonizes polyamine activity via NMDA receptor glutamine binding site, thereby modulating inotropic stasis and reducing stool volume (anti-diarrhea). However, due to the toxic effects from metabolites of DEHSP, other tetramine derivatives with less toxicity have been developed.
N1,N4-Bis[4-(ethylamino)butyl]-1,4-butanediamine Basic Attributes
286.50000
286.50
8G6X94GNHO
741423
DTXSID20152459
C2412
Drug Information
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells. (See all compounds classified as Radiation-Sensitizing Agents.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
1,14-bis(ethylamino)-5,10-diazatetradecane
Computed Properties
Molecular Weight:286.50
XLogP3:1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:17
Exact Mass:286.30964723
Monoisotopic Mass:286.30964723
Topological Polar Surface Area:48.1
Heavy Atom Count:20
Complexity:147
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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