Iododoxorubicin
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Iododoxorubicin
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CAS No:
83997-75-5
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Formula:
C27H28INO10
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Chemical Name:
Iododoxorubicin
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Synonyms:
5,12-Naphthacenedione,10-[[(2R,4S,5S,6S)-4-aminotetrahydro-5-iodo-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-;5,12-Naphthacenedione,10-[[(2R,4S,5S,6S)-4-aminotetrahydro-5-iodo-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S,10S)-;(8S,10S)-10-[[(2R,4S,5S,6S)-4-Aminotetrahydro-5-iodo-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;4′-Deoxy-4′-iododoxorubicin;4′-Deoxy-4′-iodoadriamycin;4′-Iodo-4′-deoxydoxorubicin;FCE 21954;Iododoxorubicin;WP 154;119485-06-2;144120-06-9
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CAS No:
Description
4'-deoxy-4'-iododoxorubicin is an organoiodine compound, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a doxorubicin. It is a conjugate acid of a 4'-deoxy-4'-iododoxorubicinium.|4'-Iodo-4'-Deoxydoxorubicin is an iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro.
Computed Properties
Molecular Weight:653.4
XLogP3:2.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:5
Exact Mass:653.07579
Monoisotopic Mass:653.07579
Topological Polar Surface Area:186
Heavy Atom Count:39
Complexity:982
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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