4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide
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4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide
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CAS No:
97919-22-7
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Formula:
C14H11ClN4O2S
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Chemical Name:
4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide
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Synonyms:
Benzenesulfonamide,4-amino-N-(5-chloro-2-quinoxalinyl)-;4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide;CQS;Chlorsulfaquinoxaline;NSC 339004;113875-41-5
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CAS No:
Description
Chlorsulfaquinoxaline has been used in trials studying the treatment of Lung Cancer and Colorectal Cancer.|Chloroquinoxaline Sulfonamide is a chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)
4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide Basic Attributes
334.78100
334.78
O0408QB48D
339004
DTXSID10243340
C982
2935009090
Characteristics
106.35000
4.40120
1.569g/cm3
576.3ºC at 760mmHg
302.3ºC
1.734
H2O < 1 (mg/mL)|pH 4 Acetate buffer < 1 (mg/mL)|pH 9 Carbonate buffer 10 - 12 (mg/mL)|0.1 N HCl < 1 (mg/mL)|0.1 N NaOH 25 - 30 (mg/mL)|MeOH 5 - 7 (mg/mL)|EtOH (95%) 4 - 6 (mg/mL)|DMSO > 50 (mg/mL)
Safety Information
Bulk: The compound is stable at room temperature and ordinary laboratory illumination for at least 90 days. In a capped glass vial and heated at 50 °C, the compound is stable for at least 90 days (HPLC). Solution: Dilute solutions (0.8 mg/mL) in 50% DMSO were stable for up to 72 hours (UV).
Computed Properties
Molecular Weight:334.8
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:334.0291245
Monoisotopic Mass:334.0291245
Topological Polar Surface Area:106
Heavy Atom Count:22
Complexity:476
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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