Product
Supplier
Encyclopedia
Inquiry
Home > Encyclopedia > RIVASTIGMINE

RIVASTIGMINE

RIVASTIGMINE structure

RIVASTIGMINE 

structure
  • CAS No:

    105601-20-5

  • Formula:

    C14H22N2O2

  • Chemical Name:

    RIVASTIGMINE

  • Synonyms:

    3-[1-(Dimethylamino)ethyl]phenyl Ethyl(methyl)carbamate;rac-Rivastigmine;Carbamic acid, N-ethyl-N-methyl-, 3-[1-(dimethylamino)ethyl]phenyl ester;Carbamic acid, ethylmethyl-, 3-[1-(dimethylamino)ethyl]pheny...;Carbamic acid, ethylmethyl-, 3-[1-(dimethylamino)ethyl]phenyl ester;Rivastigmine Impurity 23

Description

A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE.

RIVASTIGMINE Basic Attributes

250.34

250.168127949 g/mol

DTXSID70274453

N06DA03

Characteristics

32.8 Ų

1.038±0.06 g/cm3(Predicted)

316.2±34.0 °C(Predicted)

8.62±0.50(Predicted)

Drug Information

Symptomatic treatment of mild to moderately severe Alzheimer's dementia.Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

(S)-N-ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate

RIVASTIGMINE Use and Manufacturing

Uses

(±)-Rivastigmine is a brain selective acetylcholinesterase inhibitor. Nootropic.

Human drugs -> Exelon -> EMA Drug Category|Psychoanaleptics -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:250.34
XLogP3:2.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:250.168127949
Monoisotopic Mass:250.168127949
Topological Polar Surface Area:32.8
Heavy Atom Count:18
Complexity:269
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

Scan the QR Code to Share

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.