RIVASTIGMINE
-
RIVASTIGMINE
structure -
-
CAS No:
105601-20-5
-
Formula:
C14H22N2O2
-
Chemical Name:
RIVASTIGMINE
-
Synonyms:
3-[1-(Dimethylamino)ethyl]phenyl Ethyl(methyl)carbamate;rac-Rivastigmine;Carbamic acid, N-ethyl-N-methyl-, 3-[1-(dimethylamino)ethyl]phenyl ester;Carbamic acid, ethylmethyl-, 3-[1-(dimethylamino)ethyl]pheny...;Carbamic acid, ethylmethyl-, 3-[1-(dimethylamino)ethyl]phenyl ester;Rivastigmine Impurity 23
-
CAS No:
Description
A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE.
Drug Information
Symptomatic treatment of mild to moderately severe Alzheimer's dementia.Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)
(S)-N-ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate
RIVASTIGMINE Use and Manufacturing
(±)-Rivastigmine is a brain selective acetylcholinesterase inhibitor. Nootropic.
Human drugs -> Exelon -> EMA Drug Category|Psychoanaleptics -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:250.34
XLogP3:2.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:250.168127949
Monoisotopic Mass:250.168127949
Topological Polar Surface Area:32.8
Heavy Atom Count:18
Complexity:269
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes