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Bisindolylmaleimide IX

Bisindolylmaleimide IX structure

CAS No:
125314-64-9
Formula:
C25H23N5O2S
Chemical Name:
Bisindolylmaleimide IX
Synonyms:
Carbamimidothioic acid,3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester;Ro 31-8220;Bisindolylmaleimide IX;Ro 318220;811830-87-2;1059680-84-0

Description

Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It derives from a maleimide.|Ro 31-8220 is a methanesulfonate salt form, a staurosporine analog that inhibits protein kinase C and induces apoptosis. (NCI)

Bisindolylmaleimide IX Basic Attributes

Molecular Weight：

457.5 g/mol

Exact Mass：

457.55

UNII：

W9A0B5E78O

DSSTox ID：

DTXSID20154736

NCI Thesaurus Code：

C1310

Characteristics

PSA：

131 Å²

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

MeSH Entry Terms：

Ro 31 8220

Computed Properties

Molecular Weight:457.5
XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:457.15724617
Monoisotopic Mass:457.15724617
Topological Polar Surface Area:131
Heavy Atom Count:33
Complexity:845
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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RO 31-8220 METHANESULFONATE

CAS No.: 125314-64-9

Content: 99.00%

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Guide of Bisindolylmaleimide IX

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