Zardaverine
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Zardaverine
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CAS No:
101975-10-4
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Formula:
C12H10F2N2O3
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Chemical Name:
Zardaverine
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Synonyms:
3(2H)-Pyridazinone,6-[4-(difluoromethoxy)-3-methoxyphenyl]-;6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone;Zardaverine
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CAS No:
Description
Zardaverine is a pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor, a peripheral nervous system drug, an anti-asthmatic drug and a bronchodilator agent. It is an organofluorine compound and a pyridazinone.
Drug Information
Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)
6-(4-difluoromethoxy-3-methoxyphenyl)-3(2H)pyridazinone
Computed Properties
Molecular Weight:268.22
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:268.06594851
Monoisotopic Mass:268.06594851
Topological Polar Surface Area:59.9
Heavy Atom Count:19
Complexity:398
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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