Propanethiol

76.16 g/mol

76.03467143 g/mol

203-455-5

4AB0N08V2H

1492

2402

DTXSID5026750

COLORLESS, MOBILE LIQUID|Colorless liquid

1 Ų

1.81 (LogP)|log Kow = 1.81|1.81|1.7 (estimated)

0.841 at 68 °F (USCG, 1999)|0.843 g/cu cm at 20 °C|Relative density (water = 1): 0.84|0.842-0.847|0.84

-171 °F (USCG, 1999)|-113.3 °C|-113.3°C|-113 °C|-172°F

153 °F at 760 mm Hg (USCG, 1999)|67.8 °C|67.00to68.00°C.@760.00mmHg|68 °C|153°F

5 °F (USCG, 1999)|-5 °F; -20.5 °C|-20 °C|-5°F

Index of refraction: 1.4380 @ 20 °C/D|1.438

Slight (NIOSH, 2016)|0.02 M|Miscible in ethanol, ether; very soluble in acetone|SOL IN PROPYLENE GLYCOL|Soluble in ethanol, ether, acetone, benzene|In water, 1.90X10+3 mg/L at 25 °C|1.9 mg/mL at 25 °C|Solubility in water, g/100ml at 25 °C: 0.190|soluble in water, alcohol, propylene glycol and oils|Slight

155 mm Hg at 77 °F (NIOSH, 2016)|154.21 mmHg|154.2 mm Hg at 25 °C /Extrapolated/|Vapor pressure, kPa at 25 °C: 20.7 (calculated)|(77°F): 155 mmHg

Relative vapor density (air = 1): 2.63

Offensive|Characteristic odor of cabbage

BELOW 2-3 PPM SWEET ONION & CABBAGE-LIKE FLAVOR

4.83e-11 cm3/molecule*sec

0.00 atm-m3/mole|Henry's Law constant = 4.08X10-3 atm-cu m/mol at 25 °C

Forms binary azeotropic mixture with propyl alcohol (91.35%) & ternary azeotrope with water & propyl alcohol|Hydroxyl radical reaction rate constant = 4.83X10-11 cu cm/molec-sec at 25 °C

Highly flammable.|Highly flammable. Vapors explosive when exposed to heat, flame or sparks. Slightly soluble in water.

Sulfides, Organic

Highly Flammable

PROPANETHIOLS are flammable, moderately toxic liquid, stench. Explosive in the form of vapor when exposed to heat, flame or sparks. When heated to decomposition it emits toxic fumes of oxides of sulfur. Violent reaction and flash fire on contact with calcium hypochlorite [Stephenson, F. G., Chem. Eng. News, 1973, 51(26), p. 14].|PROPYL MERCAPTAN emits toxic fumes of oxides of sulfur when heated to decomposition. Reacts violently on contact with calcium hypochlorite [Chem. Eng. News, 1973, 51(26), p. 14].

-15,990 Btu/lb= -8,890 cal/g= -372x10+5 J/kg

9.195 eV

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

The vapour is heavier than air and may travel along the ground; distant ignition possible.

179 Btu/lb= 99 cal/g= 4.16x10+5 J/kg

Critical temp: 495 °F= 257 °C= 530 deg K (est); Critical pressure: 667 psia= 45.3 atm= 4.60 MN/sq m (est)

TZ7300000

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Ethyl mercaptan is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration (2,000 °F) followed by scrubbing with a caustic solution. /Ethyl mercaptan/|Incineration ... : Incinerate scrap material under controlled conditions using afterburner and a scrubber to neutralize sulfur dioxide ... . /Ethyl mercaptan/

Oxidizers, reducing agents, strong acids and bases, alkali metals, calcium hypochlorite.|An explosion occured when 10 grams of calcium hypochlorite was dumped into a beaker containing 5 milliliters of 1-propanethiol.|Calcium hypochlorite and mercaptans will react violently.

Propyl mercaptan is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Special Hazards of Combustion Products: Toxic sulfur dioxide is generated. (USCG, 1999)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. Vapour/air mixtures are explosive.|Flammable - 3rd degree

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P312, P303+P361+P353, P305+P351+P338, P330, P337+P313, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 1506 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P330, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)|Skin: No recommendation is made specifying the need for personal protective equipment for the body. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. (NIOSH, 2016)|Goggles or face shield; rubber gloves; self-contained breathing apparatus or organic canister mask.|Plastic gloves; goggles or face shield. /Ethyl mercaptan/|Where ... engineering controls are not sufficient to reduce airborne concentrations to acceptable levels respirators may be necessary to prevent pulmonary irritation and systemic effects. At low concentrations (less than 5 ppm) a chemical cartridge respirator with a half-mask facepiece and organic vapor cartridges can be used. At high concentrations, supplied air respirators, with a full facepiece, are necessary. /Thiols/|Chemical protective clothing should be selected after utilizing available performance data, consulting with the manufacturer, and then evaluating the clothing under actual use conditions. Workers should be provided with and required to use chemical protective clothing, gloves, face shield (8-inch minimum), and other appropriate protective clothing necessary to prevent skin contact with n-butyl mercaptan. Workers should be provided with and required to use splashproof safety goggles where ethyl mercaptan may come in contact with the eyes. /Ethyl mercaptan/|For more Personal Protective Equipment (PPE) (Complete) data for PROPYL MERCAPTAN (11 total), please visit the HSDB record page.|(See protection codes)

Very dangerous fire hazard.

Containers may explode in fire. ... Vapor may explode if ignited in an enclosed area.

Dry chemical, foam, carbon dioxide. Water may be ineffective.

Flashback along vapor trail may occur.

Work clothing that becomes wet should be immediately removed due to its flammability hazard.|Open flames and other ignition sources should be excluded from areas where thiols, especially the more volatile ones, are used. Emergency procedures and routine work practices should emphasize proper handling, containment of spills... The primary purpose of control measures is to reduce the potential for inhalation or skin contact with thiols, with special emphasis on the eyes. Whenever feasible, control at the source of exposure should be implemented. This may involve enclosure of the operation and/or the use of local exhaust ventilation. /Thiols/|Safety showers, eye wash fountains and fire extinguishers should be located in areas where appreciable amounts of thiols are used. Handwashing facilities, soap and water, should be made available to involved employees. /Thiols/|Clothing which is contaminated with ethyl mercaptan should be removed immediately and placed in closed containers for storage until it can be discarded or until provision is made for the removal of ethylmercaptan from the clothing. If the clothing is to be laundered or cleaned, the person performing the operation should be informed of ethyl mercaptan's hazardous properties. /Ethyl mercaptan/|For more Preventive Measures (Complete) data for PROPYL MERCAPTAN (12 total), please visit the HSDB record page.

/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Propanethiols/|/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Propanethiols/|/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Propanethiols/|/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Propanethiols/|For more DOT Emergency Guidelines (Complete) data for PROPYL MERCAPTAN (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritating to skin and eyes.|Contact with the liquid or vapor may irritate the skin, eyes, and mucous membranes of the upper respiratory tract.

Recommended Exposure Limit: 15 Min Ceiling Value: 0.5 ppm (1.6 mg/cu m).

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Fireproof. Cool. Keep in a well-ventilated room. Separated from strong oxidants, strong bases and strong acids.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. Exposure at high levels could cause lowering of consciousness.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

Propyl mercaptan was qualitatively detected in exhaust gases collected from the sulfate and semi-alkaline pulping processes of a Finish pulp mill(1). The compound was identified as a component of landfill gas collected from domestic waste disposal sites in Augsbach and Munich, Germany but not sewage gas collected from treatment plants in Munich, Germany(2).

Propyl mercaptan was qualitatively detected in crude oil samples collected from TX(1).

Cysteine, 2-propanethiol, and 2-mercaptoethylamine were found to potentiate the action of bradykinin on the rat blood pressure. These same thiols were ineffective on the in vitro rat ileum, although on the guinea pig ileum only 2-propanethiol was observed to be ineffective.

LC50 Rat inhalation 7,300 ppm/4 h|LD50 Rat oral 1,730 mg/kg|LD50 Rat ip 515 mg/kg|LC50 Mouse inhalation 4010 ppm/4 hr

Propyl mercaptan has been qualitatively detected in crude oil samples(1,2). The occurrence of small amounts of alkyl mercaptans in crude oil is believed to result from microbial action on elemental sulfur(2). Mercaptans are formed naturally in biological processes and exist in all living systems(2-3); the lower alkyl mercaptans, such as the propyl mercaptans, occur in manure gas from domestic animal pens(2) and have obnoxious odors at low concns(2-4). Propyl mercaptan has been identified in the volatile products of freshly crushed onion and related plant bulbs(5).

Propyl mercaptan's production and use as a synthetic flavoring agent, chemical intermediate, gas odorant(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 230(SRC), determined from a log Kow of 1.81(2) and a regression-derived equation(3), indicates that propyl mercaptan is expected to have moderate mobility in soil(SRC). Volatilization of propyl mercaptan from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.08X10-3 atm-cu m/mole(4). Propyl mercaptan is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 154 mm Hg(5). Slow bio-oxidation using a Warburg respirometer with Alcaligenes faecalis(6) suggests that biodegradation is not an important environmental fate process.|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 230(SRC), determined from a log Kow of 1.81(2) and a regression-derived equation(3), indicates that propyl mercaptan is expected to adsorb moderately to suspended solids and sediment(SRC). Volatilization from water surfaces is expected to be an important environmental fate process(3) based upon a Henry's Law constant of 4.08X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.6 hours and 3.5 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 5(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The concentration of propyl mercaptan decreased over a distance of 0 to 54 meters using lysimeters to simulate dump leachate movement in groundwater indicating biotic degradation in soil(7); however, slow biooxidation using a Warburg test(8) suggests that biodegradation not an important environmental fate process(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propyl mercaptan, which has an extrapolated vapor pressure of 154 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase propyl mercaptan is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 8 hours(SRC), calculated from its rate constant of 4.83X10-11 cu cm/molecule-sec at 25 °C(3). Propyl mercaptan does not absorb light at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight.

The rate constant for the vapor-phase reaction of propyl mercaptan with photochemically-produced hydroxyl radicals is 4.83X10-11 cu cm/molecule-sec at 25 °C(1). Values of 5.3X10-11 and 4.59X10-11 cu cm/molecule-sec at 25 °C have also been reported(2,3). These correspond to an atmospheric half-life of about 8 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The hydroxyl radical reaction proceeds primarily through OH addition to the sulfur(1); based upon chamber experiments with similar sulfur compounds(4), the reaction products may include propylsulfonic acid(SRC). Propyl mercaptan is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(5). Propyl mercaptan does not absorb light at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight.

An estimated BCF of 5 was calculated for propyl mercaptan(SRC), using a log Kow of 1.81(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of propyl mercaptan is estimated as 230(SRC), using a log Kow of 1.81(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propyl mercaptan is expected to have moderate mobility in soil.

The Henry's Law constant for propyl mercaptan is 4.08X10-3 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that propyl mercaptan is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 3.5 days(SRC). Propyl mercaptan's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Propyl mercaptan is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 154 mm Hg(3).

Propyl mercaptan was qualitatively detected in the volatile components of raw chicken breast muscle(1). It was also detected not quantified as a beef volatile component(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2,435 workers are potentially exposed to propyl mercaptan in the USA(1). Occupational exposure to propyl mercaptan may occur through inhalation and dermal contact with this compound at workplaces where propyl mercaptan is produced or used(SRC). The general population may be exposed to propyl mercaptan via inhalation of certain raw food aromas, such as onion, chicken, and beef(SRC).

The enzyme system responsible for conversion of endogenous toxic mercaptans into nontoxic thioether products via methylation, ie, alkane thiol s-methyltransferase is located in endoplasmic reticulum and can be extracted through detergent solubilization. /Mercaptans/|...May directly be oxidized and readily excreted as propane sulfate. Propylmercaptan binds to microsomal cytochrome P-450 in vitro and inhibits carbonic anhydrase. ... Completely inhibits formation of sclerotium in Sclerotimus rolfsii. Propylmercaptan can be degraded by enzymatic action of liver microsomes.|Simple aliphatic and aromatic thiols undergo S-methylation in mammals to produce the corresponding methyl thioether or sulfide. Methylation is catalysed by thiopurine methyltransferase in the cytoplasm and thiol methyltransferase in microsomes, and both reactions require S-adenosyl-l-methionine as a methyl group donor. Thiopurine methyltransferase is present in human liver, kidney, and erythrocytes; preferential substrates for this enzyme include aromatic and heterocyclic thiols. S-Methylation of aliphatic thiols is catalysed by microsomal thiol methyltransferase, and the resulting methyl thioether (sulfide) metabolite would undergo S-oxidation to give the methyl sulfoxide and methyl sulfone analogues as urinary products. Thiols may react with glutathione and other endogenous thiol substances to form mixed disulfides. Both microsomal and cytoplasmic thioltransferasess have been reported to catalyse the formation of mixed disulfides. The resulting mixed disulfides can undergo reduction back to thiols, oxidative desulfuration, or oxidation to a sulfonic acid via the intermediate thiosulfinate and sulfinic acids. The principal form in the circulation would probably be a mixed disulfide formed with albumin. /Simple thiols/

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)|Inhalation causes muscular weakness, convulsions, and respiratory paralysis; high concentrations may cause pulmonary irritation. Contact with liquid causes irritation of eyes and skin. Ingestion causes irritation of mouth and stomach. (USCG, 1999)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)|Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 m1/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Sulfur and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Early intubation at the first sign of upper airway obstruction may be necessary. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Sulfur and related compounds/

/SIGNS AND SYMPTOMS/ Inhalation causes muscular weakness, convulsions, and respiratory paralysis; high concentrations may cause pulmonary irritation.|/SIGNS AND SYMPTOMS/ ...The strong, offensive smell of propyl mercaptan can cause headache and nausea in humans. Contact with the liquid or vapor may irritate the skin, eyes, and mucous membranes of the upper respiratory tract. Acute respiratory effects were associated with propyl mercaptan exposure from potato fields treated with the pesticide ethoprop. High concentrations of vapor can cause a sense of coldness at the extremities, tachycardia, pulmonary irritation, cyanosis, respiratory paralysis, and unconsciousness.|/SIGNS AND SYMPTOMS/ In the manufacture of rubber, irritant contact dermatitis may occur from a variety of acids, alkalies, detergents, and solvents used in the process. Allergic contact dermatitis occurs not infrequently and is almost always due to an organic accelerator or antioxidant. /Mercapto compounds/|/CASE REPORTS/ Soon after ethoprop (Mocap) had been used to treat a potato field adjacent to Dorris, California, nearby residents began complaining of shortness of breath, dizziness, and an onion like odor. The nematocide Mocap had been applied to a 145 acre field at 118 pounds/acre (11.8 pounds/acre as the active ingredient) after seed potatoes were planted. Mocap was air blasted onto the soil, and tilled in; the field was then irrigated. N-Propyl-mercaptan (107039), a contaminant and degradation product of Mocap, has a characteristic onion like odor. This prompted a survey of the entire population of the town (population 1000). Most of the houses in the town were within 0.8 kilometers of the edge of the potato field. Health survey questionnaires were completed by 421 residents. Headache, diarrhea, runny nose, sore throat, burning/itching eyes, fever, hay fever attacks and asthma attacks had the most highly elevated health effect incidence risks. While the residents of the town did appear to experience an increase in symptoms associated with exposure to n-propyl-mercaptan, this increase was not strictly a function of proximity of the resident to the sprayed field. With the exception of skin rash, the perception of odor appeared related significantly to the occurrence of symptoms. The stronger the perceived odor and the longer its duration, the greater the number of effects reported and their severity. The authors recommend that human exposure to n-propyl-mercaptan be minimized to the extent practicable through restricted applications and modified agricultural uses.

1-propylmercaptan

The substance can be absorbed into the body by inhalation and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, nose, throat, respiratory system; headache, nausea, dizziness, cyanosis; In Animals: liver, kidney damage

Cough. Drowsiness. Dizziness. Headache. Nausea.

Redness.

Redness. Pain.

Eyes, skin, respiratory system, central nervous system, blood, liver, kidneys

Grade: 95%

All other basic organic chemical manufacturing|1-Propanethiol: ACTIVE

Propyl mercaptan can be separated & determined by gas chromatography, & identified by mass spectroscopy.|Sulfur-specific detection of propyl mercaptan in air by photoionization in a multiple detector GC system.|Determination of volatile sulfur compounds, including propyl mercaptan, in air at the parts per trillion level by Tenax trapping and GC with flame ionization detection.

Gas chromatography was used for the detection of mercaptan in the blood.

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index|Fire Hazards -> Flammable - 3rd degree

Flavoring Agents