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Home > Encyclopedia > Trisodium nitrilotriacetate monohydrate

Trisodium nitrilotriacetate monohydrate

Trisodium nitrilotriacetate monohydrate structure

Trisodium nitrilotriacetate monohydrate 

structure
  • CAS No:

    18662-53-8

  • Formula:

    C6H9NO6.H2O.3Na

  • Chemical Name:

    Trisodium nitrilotriacetate monohydrate

  • Synonyms:

    Glycine,N,N-bis(carboxymethyl)-,sodium salt,hydrate (1:3:1);Acetic acid,nitrilotri-,trisodium salt,monohydrate;Glycine,N,N-bis(carboxymethyl)-,trisodium salt,monohydrate;Trisodium nitrilotriacetate monohydrate;Nitrilotriacetic acid trisodium salt monohydrate

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

Nitrilotriacetic acid trisodium salt monohydrate appears as white crystals or powder with a slight odor of ammonia. pH (1% aqueous solution) about 11. pH (40%) 11-13. (NTP, 1992)|WHITE CRYSTALLINE POWDER.


Nitrilotriacetic acid trisodium salt monohydrate appears as white crystals or powder with a slight odor of ammonia. pH (1% aqueous solution) about 11. pH (40%) 11-13. (NTP, 1992)

Trisodium nitrilotriacetate monohydrate Basic Attributes

275.10 g/mol

274.99938444 g/mol

606-091-9

J0U92U6NU5

1239

DTXSID5020940

Characteristics

125 Ų

Density (at 25 °C): 1.782 g/cm³

340 °C (decomp)

greater than or equal to 100 mg/mL at 70° F (NTP, 1992)|Solubility in water, g/100ml at 25 °C: 50 (good)

Water soluble.

Amines, Phosphines, and Pyridines

NITRILOTRIACETIC ACID TRISODIUM SALT MONOHYDRATE is incompatible with oxidizers, aluminum, copper and strong acids. (NTP, 1992)

Dust explosion possible if in powder or granular form, mixed with air.

Safety Information

AJ1070000

Literature sources indicate that this chemical is noncombustible. (NTP, 1992)|Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 72 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)|In case of fire in the surroundings, use appropriate extinguishing media.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient temperatures, and keep it away from oxidizing materials and strong acids. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from strong oxidants and strong acids. Well closed.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.

This substance is possibly carcinogenic to humans.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or face shield.

Drug Information

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and eyes. Other symptoms may include irritation of the nose and throat. Contact with the powder or its dusts may result in irritation of the respiratory tract. Prolonged eye contact may lead to transient corneal injury. Ingestion causes gastric disturbances, burns to the gastrointestinal tract and vomiting. Ingestion of large amounts may cause hypocalcemic tetany with spontaneous recovery. Inhalation of the dust may cause coughing, wheezing, respiratory distress and mucous membrane irritation. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes and respiratory tract. When heated to decomposition it emits toxic fumes of nitrogen oxides, carbon monoxide and carbon dioxide. It may also emit toxic fumes of cyanide ion and Na2O. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)


Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.


Remove contaminated clothes. Rinse skin with plenty of water or shower.


First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Burning sensation. Sore throat. Cough. Laboured breathing. Shortness of breath.


Redness. Skin burns. Pain.


Redness. Pain. Severe deep burns.

Computed Properties

Molecular Weight:275.10
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:274.99938444
Monoisotopic Mass:274.99938444
Topological Polar Surface Area:125
Heavy Atom Count:17
Complexity:171
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes

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