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Home > Encyclopedia > Acodazole hydrochloride

Acodazole hydrochloride

Acodazole hydrochloride structure

Acodazole hydrochloride 

structure
  • CAS No:

    55435-65-9

  • Formula:

    C20H19N5O.ClH

  • Chemical Name:

    Acodazole hydrochloride

  • Synonyms:

    Acetamide,N-methyl-N-[4-[(7-methyl-1H-imidazo[4,5-f]quinolin-9-yl)amino]phenyl]-,hydrochloride (1:1);Acetamide,N-methyl-N-[4-[(7-methyl-1H-imidazo[4,5-f]quinolin-9-yl)amino]phenyl]-,monohydrochloride;1H-Imidazo[4,5-f]quinoline,acetamide deriv.;Acodazole hydrochloride;9-[4-(N-Methylacetamido)anilino]-7-methyl-1H-imidazo(4,5-f)quinoline hydrochloride;NSC 305884;NCI 305884

Description

Acodazole Hydrochloride is the hydrochloride salt of acodazole, a synthetic imidazoquinoline with antineoplastic activity. Acodazole intercalates into DNA, resulting in disruption of DNA replication. Use of this agent has been associated with significant cardiotoxicity.

Acodazole hydrochloride Basic Attributes

381.9 g/mol

381.1356380 g/mol

6D7W9EAH22

305884

DTXSID40204000

C71627

Characteristics

69.1 Ų

315-317 °C

H > 50 (mg/mL)|pH 4 Acetate buffer > 50 (mg/mL)|pH 9 Carbonate buffer > 50 (mg/mL)|10% Ethanol > 50 (mg/mL)|Methanol 10 - 12 (mg/mL)|95% Ethanol 10 - 15 (mg/mL)|0.1 N HCl > 50 (mg/mL)|0.1 N NaOH < 1 (mg/mL)

Safety Information

Bulk: The bulk compound did not undergo significant decomposition when heated at 60 °C for 30 days in the dark (HPLC). The compound is quite hygroscopic. Solution: A solution (0.1 mg/mL) prepared in unbuffered water and stored at room temperature and exposed to light was stable for > 48 hours (HPLC).

Computed Properties

Molecular Weight:381.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:381.1356380
Monoisotopic Mass:381.1356380
Topological Polar Surface Area:69.1
Heavy Atom Count:27
Complexity:819
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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