Triciribine phosphate
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Triciribine phosphate
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CAS No:
61966-08-3
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Formula:
C13H17N6O7P
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Chemical Name:
Triciribine phosphate
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Synonyms:
1,4,5,6,8-Pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-;1,5-Dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,4,5,6,8-pentaazaacenaphthylen-3-amine;NSC 280594;Triciribine phosphate;1,4,5,6,8-Pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-β-D-ribofuranosyl 5′-monophosphate;TCN-P;VQD 002;1023292-45-6
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CAS No:
Description
Triciribine Phosphate is the phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9.
Characteristics
189 Ų
McOH < 1 (mg/mL)|DMSO 1 - 5 (mg/mL)|DMF < 1 (mg/mL)|Trifluoroacetic acid > 50 (mg/mL)|H2O < 1 (mg/mL)|pH 4 Acetate buffer < 1 (mg/mL)|pH 9 Borate buffer 1 - 5 (mg/mL)|pH 9 Carbonate buffer 10 - 15 (mg/mL)|0.1 N HCl < 1 (mg/mL)|10% EtOH < 1 (mg/mL)|95% EtOH < 1 (mg/mL)
Safety Information
Bulk: A sample stored at 60 °C for 30 days showed no decomposition (TLC or UV). Solution: A solution (.0156 mg/mL) in pH 9 carbonate - bicarbonate buffer showed no decomposition after 9 days (UV).
Drug Information
1,4,5,6,8-pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl 5'-phosphate ester
Computed Properties
Molecular Weight:400.28
XLogP3:-3.3
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:400.08963390
Monoisotopic Mass:400.08963390
Topological Polar Surface Area:189
Heavy Atom Count:27
Complexity:663
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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