1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine
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![1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/12f7a33110d44a5b8acdb1a9bf0667fc.png "1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine")
1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine
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CAS No:
123027-56-5
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Formula:
C14H16N2O4S
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Chemical Name:
1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine
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Synonyms:
2,4(1H,3H)-Pyrimidinedione,1-[(2-hydroxyethoxy)methyl]-5-methyl-6-(phenylthio)-;1-[(2-Hydroxyethoxy)methyl]-5-methyl-6-(phenylthio)-2,4(1H,3H)-pyrimidinedione;HEPT;1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine
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CAS No:
Description
1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine is a pyrimidone that is thymine which is substituted at positions 1 and 6 by a (2-hydroxyethoxy)methyl group and a phenylsulfanyl group, respectively. It has a role as a HIV-1 reverse transcriptase inhibitor and an antiviral drug. It is a pyrimidone, an aryl sulfide and a primary alcohol. It derives from a thymine.
1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine Basic Attributes
308.35 g/mol
308.35
DTXSID80153841
Drug Information
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)|Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)
1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine
Computed Properties
Molecular Weight:308.35
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:308.08307817
Monoisotopic Mass:308.08307817
Topological Polar Surface Area:104
Heavy Atom Count:21
Complexity:433
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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