Idrapril
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Idrapril
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CAS No:
127420-24-0
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Formula:
C11H18N2O5
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Chemical Name:
Idrapril
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Synonyms:
Cyclohexanecarboxylic acid,2-[[[2-(hydroxyamino)-2-oxoethyl]methylamino]carbonyl]-,(1S,2R)-;Cyclohexanecarboxylic acid,2-[[[2-(hydroxyamino)-2-oxoethyl]methylamino]carbonyl]-,(1S-cis)-;(1S,2R)-2-[[[2-(Hydroxyamino)-2-oxoethyl]methylamino]carbonyl]cyclohexanecarboxylic acid;Idrapril
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CAS No:
Description
Idrapril is a hydroxamic, non-amino acid derivative angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Idrapril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Idrapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Computed Properties
Molecular Weight:258.27
XLogP3:-0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:258.12157168
Monoisotopic Mass:258.12157168
Topological Polar Surface Area:107
Heavy Atom Count:18
Complexity:344
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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