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xenon

xenon structure

CAS No:
14932-42-4
Formula:
Xe
Chemical Name:
xenon
Synonyms:
Xenon-133
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.|Xenon xe-133 is an Inhalation Diagnostic Agent. The mechanism of action of xenon xe-133 is as a Radiopharmaceutical Activity.|Xenon Xe-133 is a radioisotope of xenon, an element with 54 protons, having gamma emissions and a physical half-life of 5.27 days. Xenon-133 is used in the study of pulmonary function and organ blood flow.

xenon Basic Attributes

Molecular Weight：

133

Exact Mass：

132.90591 g/mol

UNII：

X3P9A5HNYF

NCI Thesaurus Code：

C47784

ATC Code：

V - Various

Characteristics

PSA：

0 Å²

Henrys Law Constant：

3.2×10-5mol/(m3Pa) at 25℃, Ercan (1979)

Drug Information

Drug Indication：

Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.

Pharmacology：

Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes and freely exchanges between blood and tissue. It tends to concentrate more in body fat than in blood, plasma, water or protein solutions.

Absorption：

Inhaled Xenon Xe 133 Gas will enter the alveolar wall and enter the pulmonary venous circulation via the capillaries.|Most of the Xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.

Biological Half-Life：

Half Life 5.245 days

Mechanism of Action：

Xenon-133 is used for the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. In the concentrations used for diagnostic purposes it is physiologically inactive.

MeSH Entry Terms：

133Xe radioisotope

xenon Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:132.90591
Exact Mass:132.90591
Monoisotopic Mass:132.90591
Heavy Atom Count:1
Isotope Atom Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes