forphenicinol
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forphenicinol
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CAS No:
71522-58-2
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Formula:
C9H11NO4
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Chemical Name:
forphenicinol
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Synonyms:
forphenicinol;α-Amino-3-hydroxy-4-(hydroxymethyl)benzeneacetic acid;Benzeneacetic acid, α-amino-3-hydroxy-4-(hydroxymethyl)-, (αS)-;BF 121;BF121;BF-121
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CAS No:
Characteristics
104 Ų
1.3075 (rough estimate)
334.28°C (rough estimate)
1.5270 (estimate)
Water: soluble
-20°C
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
alpha-amino-3-hydroxy-4-(hydroxymethyl)benzeneacetic acid
forphenicinol Use and Manufacturing
Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine. It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 μg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 μg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.
Computed Properties
Molecular Weight:197.19
XLogP3:-2.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:197.06880783
Monoisotopic Mass:197.06880783
Topological Polar Surface Area:104
Heavy Atom Count:14
Complexity:209
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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