Retelliptine
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Retelliptine
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CAS No:
72238-02-9
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Formula:
C25H32N4O
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Chemical Name:
Retelliptine
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Synonyms:
1,3-Propanediamine,N1,N1-diethyl-N3-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-;1,3-Propanediamine,N,N-diethyl-N′-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-;6H-Pyrido[4,3-b]carbazole,1,3-propanediamine deriv.;N1,N1-Diethyl-N3-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-1,3-propanediamine;BD 84;1-[3-(Diethylaminopropyl)]amino-9-methoxyellipticine;Retelliptine
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CAS No:
Description
Retelliptine is an ellipticine derivative and topoisomerase II inhibitor with antineoplastic activity. Retelliptine intercalates with DNA and inhibits topoisomerase II during DNA replication. In addition, this agent appears to induce cell cycle arrest at G2/M phase and apoptosis mediated through the Fas/Fas ligand death receptor and the mitochondrial pathway.
Drug Information
1-((3-(diethylamino)propyl)amino)-9-methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazole
Computed Properties
Molecular Weight:404.5
XLogP3:5.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:404.25761166
Monoisotopic Mass:404.25761166
Topological Polar Surface Area:53.2
Heavy Atom Count:30
Complexity:541
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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