2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide
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![2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/4defc053760048b7ba75d758e80fbf05.png "2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide")
2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide
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CAS No:
81965-43-7
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Formula:
C6H11ClN4O3
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Chemical Name:
2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide
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Synonyms:
Acetamide,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]methylamino]-;2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide;NSC 364432;SarCNU;Sarcosinamide chloroethylnitrosourea;Sarmustine;2-[[2-Chloroethyl(nitroso)carbamoyl]-methylamino]acetamide
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CAS No:
Description
2-chloroethyl-3-sarcosinamide-1-nitrosourea has been used in trials studying the treatment of Colorectal Cancer, Brain and Central Nervous System Tumors, and Unspecified Adult Solid Tumor, Protocol Specific.|SarCNU is an alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]acetamide Basic Attributes
222.63 g/mol
222.63
BHB013S3MO
364432
DTXSID90231487
C963
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide
Computed Properties
Molecular Weight:222.63
XLogP3:-1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:222.0519679
Monoisotopic Mass:222.0519679
Topological Polar Surface Area:96.1
Heavy Atom Count:14
Complexity:235
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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