ICI 164384
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ICI 164384
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CAS No:
98007-99-9
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Formula:
C34H55NO3
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Chemical Name:
ICI 164384
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Synonyms:
Estra-1,3,5(10)-triene-7-undecanamide,N-butyl-3,17-dihydroxy-N-methyl-,(7α,17β)-;(7α,17β)-N-Butyl-3,17-dihydroxy-N-methylestra-1,3,5(10)-triene-7-undecanamide;ICI 164384;ICI-M 164384
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CAS No:
Description
ICI-164384 is a 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines. It has a role as an estrogen receptor antagonist, an anti-estrogen and an antineoplastic agent. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid and a tertiary carboxamide. It derives from a 17beta-estradiol.
Drug Information
Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)
ICI 164 384
Computed Properties
Molecular Weight:525.8
XLogP3:9.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:14
Exact Mass:525.41819462
Monoisotopic Mass:525.41819462
Topological Polar Surface Area:60.8
Heavy Atom Count:38
Complexity:727
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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