2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine
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![2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/d8843be42cb84c47810ab9d5c1b1b849.png "2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine")
2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine
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CAS No:
124489-20-9
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Formula:
C13H12N4O
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Chemical Name:
2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine
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Synonyms:
2H-Imidazo[4,5-b]pyridin-2-one,1,3-dihydro-1-methyl-6-phenyl-,oxime;N-Hydroxy-PhIP;2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine;N2-Hydroxy-PhIP;2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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CAS No:
Description
N-hydroxy-PhIP is an imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. It has a role as a carcinogenic agent, a mutagen, a genotoxin, a human xenobiotic metabolite, a mouse metabolite, a rat metabolite and a neurotoxin. It is an imidazopyridine and a hydroxylamine. It derives from a PhIP.
2-(Hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine Basic Attributes
240.26 g/mol
240.26
DTXSID50154406
Drug Information
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)|Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)
N2-Hydroxy-PhIP has known human metabolites that include N2-Hydroxy-PhIP-N2-glucuronide and N2-Hydroxy-PhIP-N3-glucuronide.
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Computed Properties
Molecular Weight:240.26
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:240.10111102
Monoisotopic Mass:240.10111102
Topological Polar Surface Area:63
Heavy Atom Count:18
Complexity:282
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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