4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione
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![4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/7ccce5cd4643474881572f9610cb4ad8.png "4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione")
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione
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CAS No:
170861-63-9
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Formula:
C22H20N2O5
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Chemical Name:
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione
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Synonyms:
JTT 501;JTT-501;JTT501;Reglitazar;JTT-501;170861-63-9;4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione;JT 501;JTT 501;JTT-501;JTT501;JTT 501beta;4-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)isoxazolidine-3,5-dione;Reglitazar [INN];JTT 501beta;Reglixane;JTT 501;Reglitazar (JAN/INN);SCHEMBL362873;GTPL2670;JTT501;DB04971;PNU-182716;3,5-Isoxazolidinedione, 4-((4-(2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy)phenyl)methyl)-;NCGC00531790-01;D01971;181689-EP2269989A1;181689-EP2272825A2;Q27088527;(4RS)-4-(4-(2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy)benzyl)-3,5-isoxazolidinedione
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CAS No:
Description
Reglitazar, an isoxazolidine-3,5-dione derivative, is being developed by Pfizer for the treatment of diabetes. It is the first non-thiazolidenedione to enter clinical trials.
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione Basic Attributes
392.4 g/mol
392.13722174 g/mol
Drug Information
For the treatment of diabetes mellitus type 1 and 2.
Reglixane shows a hypoglycemic effect and also a stronger triglyceride-lowering effect than the thiazolidine-2,4-diones. In preclinical studies, reglixane has been shown to prevent several diabetic complications, such as cataract, nephropathy, and neuropathy.
Reglixane is an agonist of peroxisome proliferator-activated receptor (PPAR) gamma and alpha.
JTT 501
Computed Properties
Molecular Weight:392.4
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:392.13722174
Monoisotopic Mass:392.13722174
Topological Polar Surface Area:90.7
Heavy Atom Count:29
Complexity:572
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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