Tomentosin
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Tomentosin
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CAS No:
33649-15-9
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Formula:
C15H20O3
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Chemical Name:
Tomentosin
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Synonyms:
(3aR)-3,3aα,4,7,8,8aα-Hexahydro-7β-methyl-3-methylene-6-(3-oxobutyl)-2H-cyclohepta[b]furan-2-one;(3aα)-3-Methylene-6-(3-oxobutyl)-7β-methyl-3,3aα,4,7,8,8aα-hexahydro-2H-cyclohepta[b]furan-2-one;Tomentosin;Tomentosin (Parthenium);C09562;2H-Cyclohepta[b]furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxobutyl)-, (3aR,7S,8aR)-;(3aR,7S,8aR)-7-Methyl-3-methylene-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
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CAS No:
Description
Tomentosin is a sesquiterpene lactone.
Extracts of Inula which contain tomentosin (33649-15-9) have been used for centuries in traditional medicine for the treatment of inflammation.1 It suppresses the production of inflammatory mediators in RAW264.7 cells by inhibiting NFkB activation.2 It induces telomere shortening and caspase-dependent apoptosis in cervical cancer cells3 and induces apoptosis in human osteosarcoma MG-63 cells4. It causes G2/M arrest and apoptosis in human melanoma cell lines.5
Characteristics
43.4 Ų
1.08±0.1 g/cm3(Predicted)
121-122 °C(Solv: methanol (67-56-1))
416.2±45.0 °C(Predicted)
-20°C
Tomentosin Use and Manufacturing
Tomentosin is a antiphlogistic sesquiterpene lactone that can be isolated from Inula falconeri.Tomentosin induces apoptosis and inhibits proliferation, migration and invasion of pancreatic cancer cells[1].
Computed Properties
Molecular Weight:248.32
XLogP3:1.9
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:248.14124450
Monoisotopic Mass:248.14124450
Topological Polar Surface Area:43.4
Heavy Atom Count:18
Complexity:420
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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