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RO 20-1724

RO 20-1724 structure

CAS No:
29925-17-5
Formula:
C15H22N2O3
Chemical Name:
RO 20-1724
Synonyms:
4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE;4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE;4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE;4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE;ro 20-172;RO 20-1724;4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.|Inhibitor of phosphodiesterases.

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable

RO 20-1724 Basic Attributes

Molecular Weight：

278.35

Exact Mass：

278.35

Color/Form：

White

Characteristics

Density：

1.099±0.06 g/cm3(Predicted)

Melting Point：

125-127°

Boiling Point：

483.8±25.0 °C(Predicted)

Water Solubility：

>41.8 [ug/mL]

PKA：

14.54±0.40(Predicted)

Collision Cross Section：

174 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Critical Temperature & Pressure：

room temp

Safety Information

wgk germany：

hazard class code：

safety instructions：

26-36

Storage features：

Store at RT

Hazard Statements：

36/37/38

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)

MeSH Entry Terms：

4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

RO 20-1724 Use and Manufacturing

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.

Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.

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