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FADROZOLE HYDROCHLORIDE

FADROZOLE HYDROCHLORIDE structure

CAS No:
102676-31-3
Formula:
C14H13N3.ClH
Chemical Name:
FADROZOLE HYDROCHLORIDE
Synonyms:
FADROZOLE HYDROCHLORIDE;CGS-16949A;Fadrazole;D02451;Fadrozole hydrochloride (usan);4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride;4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920);Fadrozole HCl
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Fadrozole hydrochloride is an imidazopyridine.|A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.

Fadrozole hydrochloride is a non-steroidal imidazole derivative launched for the treatment of post-menopausal breast cancer. Fadrozole is a potent and specific aromatase inhibitor with neither androgenic nor estrogenic activities due to its structural novelty. Fadrozole exerts its action by coordinating with the iron of the porphyrin nucleus, presumably through the imidazole moiety. This strong binding competes with the binding of molecular oxygen to iron and reversibly inactivates the enzyme. An excellent clinical response rate has been reported for fadrozole with no significant side effects.

ChEBI: Fadrozole hydrochloride is an imidazopyridine.

FADROZOLE HYDROCHLORIDE Basic Attributes

Molecular Weight：

259.739

Exact Mass：

259.0876252

DSSTox ID：

DTXSID4020618

Color/Form：

Pale Beige to Pale Yellow

Characteristics

Melting Point：

231-233℃

Critical Temperature & Pressure：

room temp

Safety Information

wgk germany：

hazard class code：

safety instructions：

36/37

RTECS Number：

DI4952500

Hazard Statements：

63-22

RIDADR：

UN 2811 6.1 / PGIII

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)|Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)|Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones. (See all compounds classified as Aromatase Inhibitors.)

MeSH Entry Terms：

CGS 020286A

FADROZOLE HYDROCHLORIDE Use and Manufacturing

Fadrozole hydrochloride is a very potent and selective inhibitory effect of the aromatase enzyme system.

Antineoplastic.