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Tegoprazan

Tegoprazan structure

CAS No:
942195-55-3
Formula:
C20H19F2N3O3
Chemical Name:
Tegoprazan
Synonyms:
7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl]oxy]-N,N,2-trimethyl-3H-benzimidazole-5-carboxamide;CJ 12420;RQ-00000004;RQ-4;1H-Benzimidazole-5-carboxamide, 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-;7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide;Tegoprazan Emixustat HCL Hydrochloride;Tegoprazan
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Tegoprazan: a novel potassium-competitive acid blocker.Tegoprazan is a novel potassium-competitive acid blocker (P-CAB) showing promising in vitro and in vivo animal pharmacology activities; clinical studies showed favourable tolerability and safety as well as potent and long-lasting efficacy. P-CABs represent a new class of drugs; they exhibit rapid and effective anti-secretory activity by competitively and reversibly binding with H+/K+-ATPase on the parietal cell. Unlike conventional Proton pump inhibitors (PPIs), tegoprazan offers a rapid onset of action and full effect from the first dose as it can immediately inhibit proton pumps.10 Furthermore, since P-CABs do not require activation in the presence of gastric acid, they can be administered regardless of meals. Therefore, P-CABs are expected to have improved NAB control, overcoming the limitations of current PPIs[1].

Tegoprazan Basic Attributes

Molecular Weight：

387.38

Exact Mass：

387.13944780

UNII：

W017G7IF4S

Color/Form：

Off-white to light yellow

Characteristics

Density：

1.371±0.06 g/cm3(Predicted)

Boiling Point：

596.5±50.0 °C(Predicted)

PKA：

9.73±0.30(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Drug Information

MeSH Entry Terms：

(S)-4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo(d)imidazole-6-carboxamide

Tegoprazan Use and Manufacturing

Tegoprazan is used for remedying and treating nocturnal acid breakthrough symptoms, such as GERD, ulcer, Barrett''s esophagus, and heartburn.

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