Furosemide

The main ingredient of this product: furosemide. Chemical name: 2-[(2-furanmethyl)amino]-5-(aminosulfonyl)-4-chlorobenzoic acid. Molecular formula: C12H11ClN2O5S Molecular weight: 330.75 Excipients: sodium chloride, sodium hydroxide, water for injection

1 Adrenal glucose, mineralocorticoids, adrenocorticotropic hormone and estrogen can reduce the diuretic effect of this drug and increase the chance of electrolyte disorders, especially hypokalemia. 2 Non-steroidal anti-inflammatory analgesics can reduce the diuretic effect of this drug and increase the chance of renal damage, which is related to the former inhibiting prostaglandin synthesis and reducing renal blood flow. 3 When used in combination with sympathomimetic drugs and anticonvulsant drugs, the diuretic effect is weakened. 4 When used in combination with clofibrate (clofibrate), the effects of both drugs are enhanced, and muscle soreness and stiffness may occur. 5 When used in combination with dopamine, the diuretic effect is enhanced. 6 Drinking alcohol, alcohol-containing preparations and drugs that can cause a drop in blood pressure can enhance the diuretic and hypotensive effects of this drug; when used in combination with barbiturates and anesthetics, it is easy to cause postural hypotension. 7 This drug can reduce uric acid excretion and increase blood uric acid, so when used in combination with drugs for the treatment of gout, the dose of the latter should be appropriately adjusted. 8 Reduce the efficacy of hypoglycemic drugs. 9 It reduces the effects of anticoagulants and antifibrinolytics, mainly due to the decrease in blood volume after diuresis, which leads to an increase in the concentration of coagulation factors in the blood, and the improvement of liver blood supply and increased synthesis of coagulation factors in the liver due to diuresis. 10 This drug enhances the effect of non-depolarizing muscle relaxants, which is related to the decrease in blood potassium. 11 When used in combination with antibiotics such as amphotericin, cephalosporin, and aminoglycosides, nephrotoxicity and ototoxicity increase, especially when there is existing renal damage. 12 When used in combination with antihistamines, ototoxicity increases, and tinnitus, dizziness, and vertigo are prone to occur. 13 When used in combination with lithium, nephrotoxicity increases significantly and should be avoided as much as possible. 14 After taking chloral hydrate, intravenous injection of this drug can cause sweating, facial flushing, and increased blood pressure, which is related to the increase in thyroid hormone from a bound state to a free state, leading to enhanced catabolism. 15 When used in combination with sodium bicarbonate, the chance of hypochloremic alkalosis increases.

The main ingredient of this product is furosemide.

1. Adrenal glucose, mineralocorticoids, adrenocorticotropic hormone and estrogen can reduce the diuretic effect of this drug and increase the chance of electrolyte disorders, especially hypokalemia. 2. Non-steroidal anti-inflammatory analgesics can reduce the diuretic effect of this drug and increase the chance of renal damage, which is related to the former inhibiting prostaglandin synthesis and reducing renal blood flow. 3. When used in combination with sympathomimetic drugs and anticonvulsant drugs, the diuretic effect is weakened. 4. When used in combination with clofibrate (clofibrate), the effects of both drugs are enhanced, and muscle soreness and stiffness may occur. 5. When used in combination with dopamine, the diuretic effect is enhanced. 6. Drinking alcohol, alcohol-containing preparations and drugs that can cause a decrease in blood pressure can enhance the diuretic and antihypertensive effects of this drug; when used in combination with barbiturates and anesthetics, it is easy to cause postural hypotension. 7. This drug can reduce uric acid excretion and increase blood uric acid, so when used in combination with drugs for the treatment of gout, the dose of the latter should be appropriately adjusted. 8. Reduce the efficacy of hypoglycemic drugs. 9. Reduce the effects of anticoagulants and antifibrinolytic drugs, mainly due to the decrease in blood volume after diuresis, which leads to an increase in the concentration of coagulation factors in the blood, and the improvement of liver blood supply and the increase of coagulation factors synthesized by the liver due to diuresis. 10. This drug enhances the effect of non-depolarizing muscle relaxants, which is related to the decrease in blood potassium. 11. When used in combination with antibiotics such as amphotericin, cephalosporin, and aminoglycosides, nephrotoxicity and ototoxicity increase, especially when there is original renal damage. 12. When used in combination with antihistamines, ototoxicity increases, and tinnitus, dizziness, and vertigo are prone to occur. 13. Nephrotoxicity increases significantly when used in combination with lithium, which should be avoided as much as possible. 14. After taking chloral hydrate, intravenous injection of this drug can cause sweating, facial flushing, and increased blood pressure, which is related to the increase in thyroid hormone from bound state to free state, leading to enhanced decomposition. 15. When used in combination with sodium bicarbonate, the chance of hypochloremic alkalosis increases.