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Betamethasone

Betamethasone structure

CAS No:
378-44-9
Formula:
C22H29FO5
Chemical Name:
Betamethasone
Synonyms:
17,21-trihydr;betamethasone standard;(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;Betamethasone Base & Salts;Betamethasone,9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone;Betamethasone (200 mg);BetaMethasone (Celestone);BetaMethasone SolutioM

Description

White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless.

Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy.

Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions. Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.

White to Off-White Solid

ChEBI: Betamethasone is a glucocorticoid, a 20-oxo steroid, a 21-hydroxy steroid, a 17alpha-hydroxy steroid, a fluorinated steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug, an anti-asthmatic agent and an immunosuppressive agent. It derives from a hydride of a pregnane.

Betamethasone Basic Attributes

Molecular Weight：

392.47

EC Number：

206-825-4

Color/Form：

White to Off-White

HScode：

29379000

Characteristics

Density：

1.1283 (estimate)

Melting Point：

235-237°C

Boiling Point：

568.2±50.0 °C(Predicted)

Refractive Index：

118 ° (C=1, Dioxane)

Water Solubility：

58mg/L(25 ºC)

Toxicity：

LD50 oral in mouse: > 4500mg/kg

Flammability characteristics：

Non flammable

PKA：

12.13±0.70(Predicted)

Critical Temperature & Pressure：

0-6°C

Safety Information

wgk germany：

hazard class code：

Xi,Xn,T

safety instructions：

22-36-45-53

RTECS Number：

TU4000000

Hazard Statements：

40-48/20/21-61

Betamethasone Use and Manufacturing

Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.

glucocorticoid, antiinflammatory

Betamethasone is a glucocorticoid used as an anti-inflammatory agent.

anti-inflammatory, immunosuppressive

Drug Function and Efficacy

Not clearly described

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Betamethasone
Specifications	－－－－

Betamethasone cream
Ingredients	16beta;-methyl-11beta;,17alpha;,21-trihydroxy-9alpha;-pregnane-1,4-diene-3,20-dione
Indication	1. Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by it. 7. When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. 10. When used in combination with cardiac glycosides, it can increase the occurrence of digitalis toxicity and arrhythmia. 11 When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12 When used in combination with ephedrine, its metabolic clearance can be enhanced. 13 When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14 It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15 It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16 When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17 When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.
Specifications	0.1%
Manufacturer	Shanghai CP GENERAL Pharmaceutical Co., Ltd.

Betamethasone
Specifications	－－－－
Manufacturer	Henan LIHUA Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

AURISCO PHARMACEUTICAL CO LTD

United States
Active
MSD International GmbH (Singapore Branch)

United States
Active
Zhejiang Xianju Xianle Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Learn More Other Chemicals

betamethasone acetate phosphate, disodium salt

52081-45-5
Betamethasone dipropionate, betamethasone sodium phosphate drug combination

63211-75-6
Betamethasone dipropionate mixture with Clotrimazole

92522-91-3
Betamethasone 21-valerate Formula

2240-28-0
Betamethasone 9,11-epoxide 17,21-dipropionate Formula

66917-44-0
Betamethasone sodium phosphate Formula

151-73-5
Betamethasone dipropionate Structure

5593-20-4
Betamethasone 9,11-epoxide Structure

981-34-0
What is Betamethasone 21-Acetate-17-propionate

5514-81-8
What is BETAMETHASONE 21-PROPIONATE

75883-07-7

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Guide of Betamethasone

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Learn More Other Chemicals

Betamethasone

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