Betamethasone dipropionate
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Betamethasone dipropionate
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CAS No:
5593-20-4
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Formula:
C28H37FO7
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Chemical Name:
Betamethasone dipropionate
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Synonyms:
Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-,(11β,16β)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17,21-trihydroxy-16β-methyl-,17,21-dipropionate;(11β,16β)-9-Fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione;β-Methasone 17,21-dipropionate;Betamethasone dipropionate;Diprosone;S 3440;Diproderm;Betamethasone 17,21-dipropionate;Diprolene;Diprosis;Psorion;Maxivate;Rinderon DP;Diprophos;Sch 11460;Diprospan;Diprosen
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Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System
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CAS No:
Description
Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
Betamethasone dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasis in adult patients. It has a role as an antipsoriatic. It is a steroid ester, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a propanoate ester and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a betamethasone.|Betamethasone Dipropionate is the 17,21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone dipropionate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
Betamethasone dipropionate Basic Attributes
504.58800
504.59
227-005-2
826Y60901U
DTXSID2022672
C47963
29372290
Characteristics
106.97000
3.81750
Powder
1.24g/cm3
232 °C (decomp)
603.2ºC at 760mmHg
318.6ºC
69 ° (C=1, Dioxane)
-20ºC Freezer
LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82
218.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
2
S22; S24/25
TU4058000
|Danger|H330 (33.02%): Fatal if inhaled [Danger Acute toxicity, inhalation]|P201, P202, P260, P264, P270, P271, P273, P281, P284, P304+P340, P308+P313, P310, P314, P320, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 108 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
augmented betamethasone dipropionate
Betamethasone dipropionate Use and Manufacturing
Glucocorticoid. Used as anti-inflammatory and antibacterial ointment for dermatosis.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:504.6
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:504.25233168
Monoisotopic Mass:504.25233168
Topological Polar Surface Area:107
Heavy Atom Count:36
Complexity:1050
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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