Chlorothiazide
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Chlorothiazide
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CAS No:
58-94-6
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Formula:
C7H6ClN3O4S2
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Chemical Name:
Chlorothiazide
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Synonyms:
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide;2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-,1,1-dioxide;Aldoclor;Alurene;Chloriazid;Chlorosal;Chlorothiazid;Chlortiazid
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CAS No:
Description
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrasein vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.
Off-White Solid
ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.
Crystals; white powder.
Moderately_toxic by intraperitoneal and intravenous routes. Mddly toxic by ingestion. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx NOx and Cl-.
Characteristics
1.7303 (rough estimate)
342-343°C
608.8±65.0 °C(Predicted)
1.6100 (estimate)
<0.1 g/100 mL at 19.5 ºC
6.85, 9.45(at 25℃)
Insoluble in water.
Alkaline aqueous solutions will decompose on standing or heating .
2-8°C
Safety Information
2
Xn
36
DK9450000
42/43-20/21/22
Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.
Chlorothiazide Use and Manufacturing
Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.