Carbonic acid, thallium(1+) salt (1:2)

468.78

469.93400

249-868-4

H673633FTH

1221

1707

DTXSID1024332

HEAVY, SHINY, COLORLESS OR WHITE CRYSTALS|COLORLESS, MONOCLINIC CRYSTALS

35.53000

0.06820

Heavy, shiny, colorless or white crystals. Used in the manufacture of imitation diamonds. Also used in analysis to test for carbon disulfide and as a fungicide. (EPA, 1998)

7.1 g/cm³

272 °C

333.6 °C

g/100g H2O: 5.3 (20°C), 12.2 (60°C), 27.2 (100°C) [LAN05]; insoluble alcohol [MER06]

Less than 1X10-6 mm Hg at 25 °C

Oral-rat LDL0: 23 mg/kg; Oral-Mouse LD50: 21 mg/kg

Non-combustible; Fire produces toxic thallium oxide fumes

SLIGHTLY ALKALINE TASTE

Heat of fusion 4400 cal/g mole; 9.5 cal/g|Exists in two oxidation states, /thallous/ (Tl(I)) and /thallic/ (Tl(III)). /Thallium/|In reducing environments, thallous may precipitate as a sulfide; otherwise, it will remain in solution. /Thallium/|... Thallium(I), forms relatively few complexes with the exception of those with halogen, oxygen, and sulfur ligands. In this & several other respects, thallium(I) has chemical properties similar to those of the alkali metal cations. /Thallium (I)/

No rapid reaction with air. No rapid reaction with water.

Carbonate Salts

THALLOUS CARBONATE is a carbonate salt. These salts react with acids to release carbon dioxide and water. This reaction is often exothermic.

II

6.1

UN 1707 6.1/PG 2

3

26/28-33-51/53-24

13-28-45-61-36/37

XG4000000

T+,N

Treasury is ventilated, low temperature and dry; stored and transported separately from acids and food

Stable. Incompatible with oxidizing agents, acids.

P260-P264-P273-P280-P284-P301 + P310

H300 + H310 + H330-H373-H411

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U215, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Dithallium carbonate is a poor candidate for incineration.|Chemical Treatability of Thallium Concentration Process: Activated carbon; Chemical Classification: Metals; Scale of Study: Literature Review; Type of Wastewater Used: Unkown; Results of Study: GAC treatment after time precipitate yielded 84% reduction; /Soluble thallium cmpd/|Chemical Treatability of Thallium; Concentration Process: Chemical Precipitation; Chemical Classification: Metals; Scale of Study: Literature Review; Type of Wastewater Used: Unknown; Results of Study: 54% reduction with lime. /Soluble thallium cmpd/|Chemical Treatability of Thallium; Concentration Process: Chemical Precipitation; Chemical Classification: Metals; Scale of Study: Pilot Scale; Type of Wastewater Used: Synthetic wastewater; Results of Study: 30% reduction with ferric chloride, 31% reduction with aluminum (3 coagulants used: 220 ppm of alum @ pH= 6.4. 40 ppm of ferric chloride @ pH= 6.2, 415 ppm of lime @ pH= 11.5; Chemical coagulation was followed by dual media filtration.) /Soluble thallium cmpd/

USEPA; Ambient Water Quality Criteria Doc: Thallium (1980) EPA 440/5-80-074|RANGEL GUERRA R ET AL; THALLIUM INTOXICATION: CLINICAL EXPERIENCE WITH 14 CASES; REV INVEST CLIN 32 (4): 381-90 (1980). CLINICAL EXPERIENCE WITH 14 CASES OF THALLIUM INTOXICATION IS DISCUSSED.|Ludolph A et al; Trace Elem Med 3 (3): 121-5 (1986). Clinical and electrophysiological data from chronic thallium exposure in cement plant workers are presented.|Sharma J et al; Toxicol Environ Chem 11 (2) (1986). A review with 152 references on environmental pollution by thallium, and its toxicity and metabolism in humans and laboratory animals.|For more Special Reports (Complete) data for DITHALLIUM CARBONATE (7 total), please visit the HSDB record page.

When heated to decomposition, it emits toxic fumes of thallium. (Non-Specific -- Thallium Salts, n.o.s.) Fire may produce irritating or poisonous gases. (EPA, 1998)|Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P273, P284, P301+P310, P304+P340, P310, P314, P320, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H300+H310+H330 (86.36%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P260, P262, P264, P270, P271, P273, P280, P284, P301+P310, P302+P350, P304+P340, P310, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Ventilate area of spill. For small quantities, sweep onto paper or other suitable material, place in sealed container for disposal. Large quantities may be reclaimed. If this is not practical, collect in most convenient and safe manner and deposit in sealed containers. For liquids absorb in vermiculite, dry sand, earth or similar material and place in sealed containers for disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Respirator selection: 0.5 mg/cu m: Any dust and mist respirator, if not present as a fume. 1 mg/cu m: Any dust and mist respirator except single-use and quarter-mask respirators, if not present as a fume/Any supplied-air respirator. 2.5 mg/cu m: Any supplied-air respirator operated in a continuous flow mode/Any powered, air-purifying respirator with a dust and mist filter, if not present as a fume. 5 mg/cu m: Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter/Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode/Any powered, air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter/Any self-contained breathing apparatus with a full facepiece/Any supplied-air respirator with a full facepiece. 15 mg/cu m: Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Emergency or planned entry into unknown concentrations or IDLH conditions: Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode/Any supplied-air respirator that has a full face piece and is operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode. Escape: Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter/Any appropriate escape-type, self-contained breathing apparatus. /Thallium (soluble cmpds, as Tl/

Water, carbon dioxide, foam, dry chemical. /Soluble thallium cmpd/

If employees' clothing may have become contaminated with soluble thallium compounds, employees should change into uncontaminated clothing before leaving the work premises. Clothing contaminated with soluble thallium compounds should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of soluble compounds from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the soluble thallium compounds, the person perfoming the operation should be informed of soluble thallium compounds's hazardous properties. Non-impervious clothing which becomes contaminated with soluble thallium compounds should be removed promptly and not reworn until the soluble thallium compound is removed from the clothing. /Soluble thallium compounds/|Skin that becomes contaminated with soluble thallium compounds should be promptly washed or showered to remove any soluble thallium compounds. Eating and smoking should not be permitted in areas where soluble thallium compound is handled, processed, or stored. Employees who handle soluble thallium compounds should wash their hands thoroughly before eating, smoking, or using toilet facilities. /Soluble thallium compounds/

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 0.1 mg/cu m. Skin Designation. /Thallium, soluble compounds, as Tl/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance and complete protective clothing. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Provision to contain effluent from fire extinguishing. Store only in original container. Well closed. Separated from strong acids, strong oxidants and food and feedstuffs. Store in an area without drain or sewer access.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance may cause effects on the gastrointestinal tract, central nervous system and peripheral nervous system. Exposure could cause hair loss. Ingestion of large amounts could cause effects on the cardiovascular system, kidneys and liver. Ingestion of large amounts could cause death. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the nervous system. May cause hair loss.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!

Use local exhaust or breathing protection.

Protective clothing. Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

U215; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.5 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

U215; As stipulated in 40 CFR 261.33, when thallium(I) carbonate, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

most toxic

RETENTION OF THALLIUM IN ORGAN TISSUES IS PROLONGED; 45% OF AN INGESTED DOSE OF DITHALLIUM CARBONATE (TL2CO3) WAS STILL PRESENT IN THE HUMAN BODY AFTER 25 DAYS, & THALLIUM COULD BE DETECTED IN CEREBROSPINAL FLUID. SIMILAR THALLIUM RETENTION WAS RECORDED IN DOGS & GEESE.|In acute thallium poisoning, human brain areas densely populated with neurons were found to accumulate thallium more than other areas, and the gray matter contained higher thallium levels than nonneural tissues. /Soluble thallium cmpd/

BODY BURDEN AS % OF ADMIN DOSE WAS DETERMINED IN RATS FOLLOWING ADMIN OF (204)THALLIUM ... OVER A PERIOD OF 21 DAYS. BODY CLEARANCE /OCCURRED/ ... EXPONENTIALLY WITH HALFTIME 3.3 DAYS ... AT THE END OF 21 DAYS ... 1% OF ADMIN DOSE REMAINED. ... WITH BIOLOGICAL HALF-TIME OF 3.3 DAYS ... DAILY DOSING /GIVES/ AN EQUILIBRIUM ... @ 20 DAYS. /SOLUBLE THALLIUM SALTS/

... STUDY INVOLVING /THALLIUM SOLUBLE SALTS EFFECTS ON MOUSE CELL CULTURES SHOWED/ ... CYTOPATHIC EFFECTS ... GREATLY ENLARGED MITOCHONDRIA IN AXONS OF PERIPHERAL NERVE FIBERS. ... MECHANISM /CONCERNS INACTIVATION OF/ ... SH GROUPS THAT /ALLOW/ ... INCR PERMEABILITY OF MITOCHONDRIA LEADING TO WATER INFLUX & SWELLING. /THALLIUM CMPD/|TRIVALENT THALLIUM COMPOUNDS ARE SOMEWHAT LESS TOXIC THAN ARE THALLIUM ION COMPOUNDS ... THALLIUM ACTS AS A MITOTIC AGENT & GENERAL CELLULAR POISON. CELLULAR ACCUM OF THALLIUM IN MUSCLE & OTHER TISSUES CAUSES DERANGEMENT OF NORMAL CELLULAR METABOLISM ... HIGH THALLIUM CONCN IN BLOOD AGGLUTINATES ERYTHROCYTES & LYSES THEM FOLLOWING THALLIUM ION ACCUMMULATION WITHIN ERYTHROCYTES. /THALLIUM SALTS/|Thallium inhibits enzymes, but nothing is really known of a biochemical lesion. In fatal cases, there usually is extensive peripheral paralysis and cardiovascular involvement. The immediate cause of death may be peripheral respiratory failure of cardiac arrest. /Thallium/

Thallium is a digestive tract irritant and nervous system toxicant. It is classified as extremely toxic. Probable oral lethal dose (humans) is 5-50 mg/kg, or between 7 drops and 1 teaspoon for 70 kg person (150 lb.). Teratogenic effects are noted after chronic intoxication. (EPA, 1998)

Warning: Effects may be delayed. Caution is advised. Signs and Symptoms of Acute Thallous Carbonate Exposure: Signs and symptoms of acute exposure to thallous carbonate may be severe and include bronchitis, pneumonia, and respiratory paralysis. Tachycardia (rapid heart rate) may occur. Victims may experience headache, delirium, dementia, depression, psychosis, and peripheral burning sensations with severe pain. Muscle weakness, ptosis (drooping eyelids), strabismus (loss of coordination between eyes), incoordination, spasmodic movements, convulsions, seizures, shock, and coma may also occur. Gastrointestinal effects include increased salivation, inflammation of the oral cavity, anorexia, vomiting (may be bloody), diarrhea (may be bloody), abdominal pain, and constipation. Kidney damage has been reported. Emergency Life-Support Procedures: Acute exposure to thallous carbonate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to thallous carbonate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to thallous carbonate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of thallous carbonate is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of thallous carbonate may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. (EPA, 1998)

Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention .

Rinse with plenty of water (remove contact lenses if easily possible).

Thallium is a skin sensitizer and cumulative poison which is toxic by ingestion, inhalation or skin absorption. /Soluble thallium compounds/

thallium (+1) carbonate

The substance can be absorbed into the body by ingestion and through the skin.

Cough. See Ingestion.

MAY BE ABSORBED! See Ingestion.

Carbonic acid, thallium(1+) salt (1:2): ACTIVE

Analyte: Thallium; Matrix: air; Procedure: Atomic absorption spectroscopy; wavelength 278.6 nm; Range: 0.034-0.15 mg/cu m; Precision 0.060; Interferences: the presence of insoluble thallium compounds ... therefore, it is necessary to obtain a bulk sample to test for solubility. /Soluble thallium cmpd/|ANALYTE: THALLIUM, MATRIX: AIR, PROCEDURE: FILTER COLLECTION, ACID DIGESTION, ATOMIC ABSORPTION SPECTROPHOTOMETRY, RANGE: 5-20 UG/ML, 210-840 UG/CU M. /SOLUBLE THALLIUM COMPOUNDS/|Procedure Samp(1): Atomic absorption spectrophotometer, having a monochromator with a reciprocal linear dispersion of about 6.5 Angstrom/mm in the ultraviolet region. The instrument must be equipped with an air-acetylene burner head. Precision: Coefficient of variation= 0.060. /Soluble thallium cmpd/|Atomic absorption spectrophotometer, having a monochromator with a reciprocal linear dispersion of about 6.5 Angstrom/mm in the ultraviolet region. The instrument must be equipped with an air-acetylene burner head. Precision: Coefficient of variation= 0.060. /Soluble thallium cmpd/