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Home > Encyclopedia > Oxprenolol hydrochloride

Oxprenolol hydrochloride

pharmaceutical raw materials
Oxprenolol hydrochloride structure

Oxprenolol hydrochloride 

structure
  • CAS No:

    6452-73-9

  • Formula:

    C15H23NO3.ClH

  • Chemical Name:

    Oxprenolol hydrochloride

  • Synonyms:

    2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-,hydrochloride (1:1);2-Propanol,1-[o-(allyloxy)phenoxy]-3-(isopropylamino)-,hydrochloride;2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-,hydrochloride;1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propanol hydrochloride;Ba 39089;CIBA 39089Ba;1-Isopropyl-amino-2-hydroxy-3-(O-allyloxyphenoxy)propane hydrochloride;Oxprenolol hydrochloride;1-Isopropylamino-3-(o-allyloxyphenoxy)-2-propanol hydrochloride;1-(2′-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propranol-hydrochloride;1-(2-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;Slow-Trasicor;(±)-1-[o-(Allyloxy)phenoxy]-3-isopropylamino-2-propanol hydrochloride;dl-Oxprenolol hydrochloride;(±)-Ba 39089;Trasicor;(±)-Oxprenolol hydrochloride;dl-Alprenolol hydrochloride;Oxiprenolol hydrochloride;Trasicor 80;Laracor;Paritane;Trasacor;Slow-Pren;22972-97-0

  • Categories:

    Organic Chemistry  >  Amides

Description

White Solid


A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.

Oxprenolol hydrochloride Basic Attributes

301.81

301.14400

229-260-5

DTXSID5021093

2922509090

Characteristics

50.7

3.18200

White Solid

107-109 °C

403.3ºC at 760 mmHg

197.7ºC

Store at +4°C

Oral-rat LD50: 900 mg/kg

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes

Safety Information

IRRITANT

UN 2811 6.1 / PGIII

UA5277000

Xi

Treasury is ventilated, low temperature and dry; stored separately from food materials

P264, P270, P273, P301+P310, P301+P312, P321, P330, P405, P501

H301

|Danger|H301 (66.67%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P301+P312, P321, P330, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

moderately toxic

Drug Information

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

Coretal

Oxprenolol hydrochloride Use and Manufacturing

Uses

β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:301.81
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:301.1444713
Monoisotopic Mass:301.1444713
Topological Polar Surface Area:50.7
Heavy Atom Count:20
Complexity:246
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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