 Home > Encyclopedia > Proglumide

Proglumide

Proglumide structure

CAS No:
6620-60-6
Formula:
C18H26N2O4
Chemical Name:
Proglumide
Synonyms:
Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-;Glutaramic acid,4-benzamido-N,N-dipropyl-,DL-;Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-,(±)-;4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid;DL-4-Benzamido-N,N-dipropylglutaramic acid;Proglumide;CR 242;Xyde;Xylamide;Xylamide (gastroprotective agent);Milid;W 5219;Binoside;Gastrotopic;Midelid;Milide;Nulsa;Ulcutin;Promide (parasympatholytic);(±)-Proglumide;DL-Proglumide;Promid;24485-90-3;25727-74-6
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Proglumide is a known cholecystokinin (CCK) antagonist.

Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as a drug metabolite, a xenobiotic metabolite, a cholinergic antagonist, an anti-ulcer drug, a cholecystokinin antagonist, a gastrointestinal drug, a delta-opioid receptor agonist and an opioid analgesic. It contains a (R)-proglumide and a (S)-proglumide.|A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

Proglumide Basic Attributes

Molecular Weight：

334.41

Exact Mass：

334.41

EC Number：

229-567-4

NSC Number：

757841

DSSTox ID：

DTXSID7023516

ATC Code：

A - Alimentary tract and metabolism

HScode：

2924299090

Characteristics

PSA：

86.7

XLogP3：

2.53

Density：

1.1±0.1 g/cm3

Melting Point：

143.5 °C

Boiling Point：

589.8±45.0 °C at 760 mmHg

Flash Point：

310.5±28.7 °C

Refractive Index：

1.534

Storage Conditions：

Refrigerator

Toxicity：

Celiac-rat LD50: 1420 mg/kg; Oral-Mouse LD50: 8070 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Collision Cross Section：

181.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Storage features：

Ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

MeSH Entry Terms：

Milid

Proglumide Use and Manufacturing

Uses

Anticholinergic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:334.4
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:334.18925731
Monoisotopic Mass:334.18925731
Topological Polar Surface Area:86.7
Heavy Atom Count:24
Complexity:413
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzoyl chloride

Drug Function and Efficacy

This product is a gastrin receptor antagonist, which can significantly inhibit the secretion of gastric acid and pepsin caused by gastrin, but has no significant effect on the gastric acid secretion caused by histamine and vagus nerve stimulation. It can increase the content of hexosamine in the gastric mucosa, promote glycoprotein synthesis, and protect and promote the healing of the gastric mucosa. It has a choleretic effect, preventing stone formation and promoting bile duct health by stimulating bile acid-independent bile secretion, changing the stone-forming factors in bile, and antagonizing CCK.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Proglumide Tablets
Ingredients	Proglumide. Its chemical name is (plusmn;)-5-dipropylamino-4-benzoylamino-5-oxo-pentanoic acid.
Indication	This product does not affect the metabolism of other drugs. If used simultaneously with other anti-ulcer drugs such as H2 receptor antagonists, it can enhance the inhibitory effect on gastric acid secretion and accelerate the healing of ulcers.
Specifications	0.2g
Manufacturer	Hebei Jiheng Pharmaceutical Co., Ltd.

Proglumide Tablets
Ingredients	Proglumide. Its chemical name is (plusmn;)-5-dipropylamino-4-benzoylamino-5-oxo-pentanoic acid.
Indication	This product does not affect the metabolism of other drugs. If used simultaneously with other anti-ulcer drugs such as H2 receptor antagonists, it can enhance the inhibitory effect on gastric acid secretion and accelerate the healing of ulcers.
Specifications	0.2 g
Manufacturer	Xi'an Lijun Pharmaceutical Co.Limited

Proglumide Tablets
Ingredients	Proglumide. Its chemical name is (plusmn;)-5-dipropylamino-4-benzoylamino-5-oxo-pentanoic acid.
Indication	This product does not affect the metabolism of other drugs. If used simultaneously with other anti-ulcer drugs such as H2 receptor antagonists, it can enhance the inhibitory effect on gastric acid secretion and accelerate the healing of ulcers.
Specifications	0.2g
Manufacturer	Nuode Pharmaceutical (Jiangsu) Co., Ltd.

See More Related Drugs

Registered Holders

Hengcheng Pharmaceutical Group Huainan Co., Ltd.

China
Active
Liaoyuan City Baikang Pharmaceutical Co., Ltd.

China
Active
Nanjing Pharmaceutical FACTORY Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Proglumide

Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of vitamin

Factory Supply Bulk Price 99% Proglumide powder 6620-60-6 with High Quality in Stock

CAS No.: 6620-60-6

Grade: Food grade

Content: 99%

Inquiry
Shandong zhishang chemical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Dichloromethane,Linocaine hydrochloride

High Quality Proglumide CAS 6620-60-6 Factory in China

CAS No.: 6620-60-6

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

Best Price 6620-60-6 Buy 99% Proglumide

CAS No.: 6620-60-6

Grade: Pharma grade ; Food Grade

Content: 99.00%

Inquiry
GIHI CHEMICALS CO.,LIMITED Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of chemicals

proglumide 99% white powder

CAS No.: 6620-60-6

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

Bulk Price 99% Proglumide CAS 6620-60-6 with High Quality in Stock

CAS No.: 6620-60-6

Grade: pharmaceutical grade

Content: 99.9%

Inquiry