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Proglumide

Proglumide structure

CAS No:
6620-60-6
Formula:
C18H26N2O4
Chemical Name:
Proglumide
Synonyms:
Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-;Glutaramic acid,4-benzamido-N,N-dipropyl-,DL-;Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-,(±)-;4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid;DL-4-Benzamido-N,N-dipropylglutaramic acid;Proglumide;CR 242;Xyde;Xylamide;Xylamide (gastroprotective agent);Milid;W 5219;Binoside;Gastrotopic;Midelid;Milide;Nulsa;Ulcutin;Promide (parasympatholytic);(±)-Proglumide;DL-Proglumide;Promid;24485-90-3;25727-74-6
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Proglumide is a known cholecystokinin (CCK) antagonist.

Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as a drug metabolite, a xenobiotic metabolite, a cholinergic antagonist, an anti-ulcer drug, a cholecystokinin antagonist, a gastrointestinal drug, a delta-opioid receptor agonist and an opioid analgesic. It contains a (R)-proglumide and a (S)-proglumide.|A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

Proglumide Basic Attributes

Molecular Weight：

334.41

Exact Mass：

334.41

EC Number：

229-567-4

NSC Number：

757841

DSSTox ID：

DTXSID7023516

ATC Code：

A - Alimentary tract and metabolism

HScode：

2924299090

Characteristics

PSA：

86.7

XLogP3：

2.53

Density：

1.1±0.1 g/cm3

Melting Point：

143.5 °C

Boiling Point：

589.8±45.0 °C at 760 mmHg

Flash Point：

310.5±28.7 °C

Refractive Index：

1.534

Storage Conditions：

Refrigerator

Toxicity：

Celiac-rat LD50: 1420 mg/kg; Oral-Mouse LD50: 8070 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Collision Cross Section：

181.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Storage features：

Ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

MeSH Entry Terms：

Milid

Proglumide Use and Manufacturing

Uses

Anticholinergic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:334.4
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:334.18925731
Monoisotopic Mass:334.18925731
Topological Polar Surface Area:86.7
Heavy Atom Count:24
Complexity:413
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzoyl chloride

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Guide of Proglumide

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
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