Linderalactone
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Linderalactone
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CAS No:
728-61-0
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Formula:
C15H16O3
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Chemical Name:
Linderalactone
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Synonyms:
6H-4,7-Methenofuro[3,2-c]oxacycloundecin-6-one,4,8,9,12-tetrahydro-3,11-dimethyl-,(4R,10E)-;Germacra-1(10),4,7,11-tetraen-15-oic acid,8,12-epoxy-6α-hydroxy-,γ-lactone,(E)-(+)-;Linderalactone;6H-4,7-Methenofuro[3,2-c]oxacycloundecin-6-one,4,8,9,12-tetrahydro-3,11-dimethyl-,[R-(E)]-;(4R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one;32663-41-5;857366-20-2
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CAS No:
Description
Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2].
Characteristics
39.44000
3.27
1.2±0.1 g/cm3
136-138 °C
437.9±45.0 °C at 760 mmHg
218.6±28.7 °C
1.572
Computed Properties
Molecular Weight:244.28
XLogP3:2.7
Hydrogen Bond Acceptor Count:3
Exact Mass:244.109944368
Monoisotopic Mass:244.109944368
Topological Polar Surface Area:39.4
Heavy Atom Count:18
Complexity:422
Defined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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