Bromotrifluoromethane

148.91

148.91

200-887-6

52231LCA7R

0837

1009

DTXSID5026415

Colorless gas [Note: Shipped as a liquefied compressed gas.]

2903760020

0

1.86

Bromotrifluoromethane appears as a colorless, odorless gas at room conditions Shipped as a liquid confined under its own vapor pressure. Noncombustible. Nontoxic but can asphyxiate by the displacement of air. Contact with the unconfined liquid can cause frostbite by evaporative cooling. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket.

1.5 g/cm³

-172 °C

-57.8 °C @ Press: 760 Torr

1.321

0.03 wt % at 20 °C (NIOSH, 1997)

Vapour pressure, kPa at 20°C: 1434

5.14

Inhalation-rat LC50: 84000 PPM/15 minutes; inhalation-mouse LC50: 381 g/m3

Non-combustible; fire produces toxic fluoride and bromide gases

Odorless gas.

1.00e-16 cm3/molecule*sec

0.50 atm-m3/mole|Henry's Law constant= 0.4994 atm-cu m/mole at 25 °C

Ionization potential: 11.78|Dipole moment: 0.65 debye

Slightly soluble in water.

Fluorinated Organic Compounds

BROMOTRIFLUOROMETHANE may react with aluminum to produce substantial heat. Other halogenated hydrocarbons, such as fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane produce sufficient heat in this way to melt aluminum pieces. The vigor of the reaction appears to depend on the degree of fluorination and the vapor pressure [Chem. Eng. News 39(27):44 1961].

11.78 eV

Nonflammable Gas

The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen.

Noncorrosive

118.7 kJ/kg @ boiling point

Critical temp: 67 °C; critical pressure: 39.2 atm

2.2

1009

20

23-36/37/39-38

PA5425000

The warehouse is ventilated, low temperature and dry; stored separately from flammable materials

Conditions contributing to instability: heat

P261, P264, P271, P280, P304+P340, P305+P351+P338, P312, P337+P313, P403+P233, P405, P410+P403, P501

H280

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.|Because of recent discovery of potential ozone decomposition in the stratosphere by fluorotrichloromethane, this material should be released to the environment only as a last resort. Waste material should be /recovered and/ returned to the vendor, or to licensed waste disposal company.

Incompatible with chemically-active metals such as calcium, powdered aluminum, zinc & magnesium.

Freons; Encyclop'edie m'edico-chirurgicale Intoxications, 18 rue S'eguier, 75006 Paris, France, 3 pages (1982). Data on freons (nomenclature, physical & chemical properties, acute & chronic toxicity), used as aerosol propellants, refrigerants, extinguishing agents, and anesthetics are reviewed.|Gros P; Cah Notes Doc 113: 535-42 (1983). The properties, toxicities and uses of the gaseous extinguishing agents (Halon 1301 & 1211) were reviewed.|Morel C et al; Cah Notes Doc 105: 629-32 (1981) Review of bromotrifluoromethane is presented with 20 references.|Geller I et al; Contract Report No. CR: NASA-CR-161078 (1981). The effects of low concn of CBrF3, under continuous exposure conditions, on the central nervous system and cardiovascular systems of animals to enable an assessment of these risks to man were investigated.|Zakhari S, Aviado DM; Cardiovascular Toxicology of Aerosol Propellants, Refrigerants and Related Solvents; Target Organ Toxicology Series: Cardiovascular Toxicology, XII+ 388 pages; Raven Press: New York, NY 281-326 (1982). Review of the toxicology of aerosol propellants, refrigerants and related solvents on the cardiovascular system of humans.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]: Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2016)|Not combustible. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire.

|Warning|H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P410+P403, P501, and P502|Aggregated GHS information provided by 254 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P261, P264, P271, P280, P304+P340, P305+P351+P338, P312, P337+P313, P403+P233, P405, P410+P403, and P501|Danger|H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]|P260, P261, P264, P270, P271, P304+P340, P307+P311, P312, P321, P403+P233, P405, P501, and P502

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin from becoming frozen from contact with the liquid or from contact with vessels containing the liquid. Eyes: Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: No recommendation is made specifying the need for removing clothing that becomes wet or contaminated. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating. (NIOSH, 2016)|Recommendations for respirator selection. Max concn for use: 10,000 ppm: Respirator Classes: Any supplied-air respirator.|Recommendations for respirator selection. Max concn for use: 25,000 ppm: Respirator Class: Any supplied-air respirator operated in a continuous flow mode.|Recommendations for respirator selection. Max concn for use: 40,000 ppm: Respirator Classes: Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.|Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Classes: Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator that has a full facepiece and is operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode.|For more Personal Protective Equipment (PPE) (Complete) data for BROMOTRIFLUOROMETHANE (12 total), please visit the HSDB record page.|(See protection codes)

MONOBROMOTRIFLUOROMETHANE IS NOT FLAMMABLE; IT IS A GOOD FIRE EXTINGUISHER.

If material involved in fire: Extingiush fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty). Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

If trifluoromonobromomethane is leaked, the following steps should be taken: 1. Ventilate area of leak. 2. Stop flow of gas.

Persons not wearing protective equipment and clothing should be restricted from areas of leaks until cleanup has been completed.|If material not involved in fire: Attempt to stop leak if without undue personnel hazard.|Personnel protection: Avoid breathing vapors. Keep upwind. Wear appropriate chemical protective gloves and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment.|SUFFICIENT EXHAUST & GENERAL VENTILATION SHOULD BE PROVIDED TO KEEP VAPOR CONCN BELOW RECOMMENDED LEVELS. /FLUOROCARBONS/|For more Preventive Measures (Complete) data for BROMOTRIFLUOROMETHANE (10 total), please visit the HSDB record page.

/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Fire or Explosion: Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.|/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.|/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for BROMOTRIFLUOROMETHANE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1000 ppm (6100 mg/cu m).

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1000 ppm (6100 mg/cu m)

Ventilation. NEVER direct water jet on liquid. Personal protection: chemical protection suit including self-contained breathing apparatus.

Fireproof if in building. Cool.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

The substance is irritating to the eyes. Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the central nervous system.

Use ventilation.

Cold-insulating gloves.

Wear safety goggles or eye protection in combination with breathing protection.

INDOOR: Bromotrifluoromethane was detected in the payload bay of the shuttle (concn not specified) from 28 separate missions(1).|RURAL/REMOTE: The concn of bromotrifluoromethane in the atmosphere at altitudes ranging from about 10 to 34 km was found to be approximately 1 part per trillion/V during 1980 monitoring(1). Bromotrifluoromethane was found at concns of 0.8 and 0.7 parts per trillion in monitoring studies conducted over the northern and southern hemisphere of the eastern Pacific Ocean, respectively(2). Bromotrifluoromethane is the main source of bromine radicals in the atmosphere above 25 km(3).

practically nontoxic

IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT OF ARRHYTHMIAS. /FLUOROCARBONS/

LC50 Rat ihl 84,000 ppm/15 mos|LC50 Guinea pig ihl 88,000 ppm/15 mos

IT IS POSSIBLE THAT PT WITH CARDIAC OR RESP DISORDERS MAY PROVE ESP SUSCEPTIBLE. /FLUOROCARBONS/

Bromotrifluoromethane's production and use in fire extinguishers(1) and suggested use as a possible refrigerant for liquified natural gas(2) may result in its release to the environment through various waste streams(SRC). However, the production of bromotrifluoromethane has to be stopped in accordance with the Montreal Protocol of 1987 as it plays an important role in the destruction of the earth's ozone layer(1). The Montreal Protocol stipulates that the production and consumption of compounds that deplete ozone in the stratosphere including halons, are to be phased out by 2000(1).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is expected to have very high mobility in soil(SRC). Volatilization of bromotrifluoromethane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 0.499 atm-cu m/mole(3). Volatilization of bromotrifluoromethane from dry soil surfaces is expected to be rapid(SRC) based upon a vapor pressure of 1.22X10+4 mm Hg(4). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 0.499 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1.2 hrs and 4.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 5.4(SRC), from its log Kow of 1.86(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups(SRC). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(9).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromotrifluoromethane, which has a vapor pressure of 1.22X10+4 mm Hg at 25 °C(2), is expected to exist solely in the gas phase in the ambient atmosphere. Gas-phase bromotrifluoromethane is slowly degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life of this reaction in air is estimated to be greater than 44 years(3), calculated from it's rate constant of <1.0X10-16 cu cm/molecule-sec at 25 °C(3). Bromotrifluoromethane has a maximum UV absorbance at 205 nm and does not appear to absorb UV light above 270 nm(4). It has an estimated photolysis lifetime in the atmosphere of 72 years(4). The primary decomposition process to occur in the stratosphere is UV photolysis(5). The stratospheric lifetime of bromotrifluoromethane has been estimated to range from 62 to 112 years(6). Therefore, when bromotrifluoromethane is released in the troposphere, it will diffuse gradually into the upper limits of the troposphere, and eventually, into the stratosphere above the ozone layer where it will degrade slowly via photolysis, contributing to ozone depletion(SRC).

The rate constant for the gas-phase reaction of bromotrifluoromethane with photochemically-produced hydroxyl radicals has been estimated as <1.0X10-16 cu cm/molecule-sec at 25 °C(1). This corresponds to an estimated atmospheric half-life greater than 44 years at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). Bromotrifluoromethane has a maximum UV absorbance at 205 nm and does not appear to absorb UV light above 270 nm(2). It has an estimated photolysis lifetime in the atmosphere of 72 years(2). Therefore, photolysis will not be an important fate process in the troposphere(SRC). The stratospheric lifetime of bromotrifluoromethane has been estimated to range from 62 to 112 years with direct photolysis being the dominant removal mechanism(3). Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups(SRC).

An estimated BCF of 5.4 was calculated for bromotrifluoromethane(SRC), using a log Kow of 1.86(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of bromotrifluoromethane is estimated as 49(SRC), using a log Kow of 1.86(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromotrifluoromethane is expected to have very high mobility in soil.

The Henry's Law constant for bromotrifluoromethane is 0.499 atm-cu m/mole(1). This Henry's Law constant indicates that bromotrifluoromethane is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 1.2 hrs(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 4.8 days(SRC). Bromotrifluoromethane's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). Volatilization of bromotrifluoromethane from dry soil surfaces is expected to be rapid(SRC) based upon a vapor pressure of 1.22X10+4 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 32 workers (0 of these are female) are potentially exposed to bromotrifluoromethane in the US(1). However, production of bromotrifluoromethane has since been banned in the U.S. and therefore occupational exposure will only occur in the use of fire extinguishers containing bromotrifluoromethane as an ingredient(2). Occupational exposure to bromotrifluoromethane may occur through inhalation and dermal contact with this compound at workplaces where bromotrifluoromethane is used(SRC). The general population may be exposed to bromotrifluoromethane via inhalation of ambient air(3,4) and from fire extinguishing products(5) containing bromotrifluoromethane. Due to its ozone depleting potential in the stratosphere(6), its use is decreasing.

... MAIN FACTOR AFFECTING FATE OF FLUOROCARBONS IS BODY FAT, WHERE THEY ARE CONCENTRATED & SLOWLY RELEASED INTO BLOOD @ CONCN THAT SHOULD NOT CAUSE ANY RISK OF CARDIAC SENSITIZATION. /FLUOROCARBONS/|THERE IS A SIGNIFICANT ACCUMULATION OF FLUOROCARBONS IN BRAIN, LIVER & LUNG COMPARED TO BLOOD LEVELS, SIGNIFYING A TISSUE DISTRIBUTION OF FLUOROCARBONS SIMILAR TO THAT OF CHLOROFORM. /FLUOROCARBONS/|Absorption of fluorocarbons is much lower after oral ingestion (35-48 times) than after inhalation. ... The lung generally has the highest fluorocarbon concentrations on autopsy. /Fluorocarbons/|Although fluorocarbons cause cardiac sensitization in certain animal species, rapid elimination prevents the development of cardiotoxic concentrations from aerosol bronchodilator use except at exceedingly high doses (12 to 24 doses in 2 minutes). /Fluorocarbons/|FLUOROCARBON COMPOUNDS ARE LIPID-SOLUBLE AND THUS ARE GENERALLY WELL ABSORBED THROUGH LUNG. ABSORPTION AFTER INGESTION IS 35 TO 48 TIMES LOWER THAN AFTER INHALATION. ... FLUOROCARBONS ARE ELIMINATED BY WAY OF LUNG. /FLUOROCARBON COMPOUNDS/

Cardiac arrhythmia, possibly aggravated by elevated levels of catecholamines due to stress ... is suggested as the cause of these adverse responses, which may lead to death. /Fluorocarbons/

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases. (ERG, 2016)

Eye: If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible. Skin: If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If the diagnosis of solvent abuse is suspected it can be confirmed by biochemical examination of the blood or urine. Emergency treatment is supportive and includes decontamination, oxygen, and any specific therapy required in a particular case such as antiarrhythmics or anticonvulsants. A few patients may require intermittent positive-pressure ventilation, dialysis, or treatment for hepatic failure. /Solvent abuse/|... In persons who are intoxicated with fluorocarbons, steps can be taken to lessen the risk of arrhythmias. ... Before evaluation at the hospital, patients should be advised to avoid strenuous exercise. In the hospital, patients can be placed in a quiet, nonthreatening environment and sedated if necessary. If hypoxic, oxygen should be administered and metabolic abnormalities corrected. Sympathomimetic drugs should be avoided. Ventricular arrhythmias are best treated with beta-blocking agents. /Fluorocarbons/|Patients with fluorohydrocarbon poisoning should not be given epinephrine (Adrenalin) or similar drugs because of the tendency of fluorohydrocarbon to induce cardiac arrhythmias, including ventricular fibrillation. /Fluorohydrocarbons/|Victims of Freon inhalation require management for hypoxic, CNS anesthetic, and cardiac symptoms. Patients must be removed from the exposure environment, and high-flow supplemental oxygen should be utilized. The respiratory system should be evaluated for injury, aspiration, or pulmonary edema and treated appropriately. CNS findings should be treated supportively. A calm environment with no physical exertion is imperative to avoid increasing endogenous adrenegic levels. Exogenous adrenergic drugs must not be used to avoid inducing sensitized myocardial dysrhythmias. Atropine is ineffective in treating bradyarrhythmias. For ventricular dysrhythmias, diphenylhydantoin and countershock may be effective. Cryogenic dermal injuries should be treated by water bath rewarming at 40 to 42 °C until vasodilatory flush has returned. Elevation of the limb and standard frostbite management with late surgical debridement should be utilized. Ocular exposure requires irrigation and slit-lamp evaluation for injury. /Freons/|For more Antidote and Emergency Treatment (Complete) data for BROMOTRIFLUOROMETHANE (7 total), please visit the HSDB record page.

... TEN TO FIFTEEN PERCENT TRIFLUOROBROMOMETHANE IN AIR CAUSED A DECR IN HUMAN SUBJECT'S PERFORMANCE OF 5 OF 6 PSYCHOMOTOR TASKS. AT 15%, A FEELING OF IMPENDING UNCONSCIOUSNESS DEVELOPED. ... SLIGHT INCR IN REACTION TIME DURING 3 MIN EXPOSURES AT 4% & 7% TRIFLUOROBROMOMETHANE. LIGHT HEADEDNESS, PARESTHESIA, & DIMINISHED PERFORMANCE ... DURING EXPOSURES UP TO 10% TRIFLUOROBROMOMETHANE. ... NO CARDIAC ARRHYTHMIAS WERE REPORTED DURING HUMAN EXPOSURES AT 4% TO 7% TRIFLUOROBROMOMETHANE FOR 3 MIN IN HYPOBARIC CHAMBERS OR AT 5% TO 7% FOR 5 MIN AT PRESSURIZED ALTITUDES OF 1,000-20,000 FEET IN AIRCRAFT FLIGHT TESTS.|Possible adverse effects of exposure to Halon 1301 during firefighting in confined spaces were investigated. Halon 1301 (7%) did not affect the normal sleep pattern or the general health of human subjects. No Halon-induced changes in serum enzymes or serum albumin or total protein levels were observed suggesting that liver function was not altered. Subjects experienced transient light-headness and mild euphoria. Mental performance was decr, but returned to normal 1/2 hr after exposure. Apparently, Halon 1301 is a medically safe agent for use in fire fighting in confined spaces.|EXPOSURE OF HUMANS TO HALON 1301 UNDER HYPOBARIC CONDITIONS DID NOT PRODUCE SIGNIFICANT CHANGES IN THE CARDIAC OR CENTRAL NERVOUS SYSTEMS. VOLUNTEERS WERE EXPOSED FOR 3 MIN TO 4 OR 7% HALON 1301 IN AIR IN A HYPOBARIC CHAMBER MAINTAINED AT 632 OR 380 MM HG.|FLUOROCARBON VAPORS ARE FOUR TO FIVE TIMES HEAVIER THAN AIR. THUS HIGH CONCN TEND TO ACCUMULATE IN LOW-LYING AREAS, RESULTING IN HAZARD OF INHALATION OF CONCENTRATED VAPORS, WHICH MAY BE FATAL. ... THE HIGHEST EXPOSURE IN THE PLANT OCCURS WITH VENTING OF GASES FROM RETURNABLE CYLINDERS. /FLUOROCARBONS/|For more Human Toxicity Excerpts (Complete) data for BROMOTRIFLUOROMETHANE (21 total), please visit the HSDB record page.

bromotrifluoromethane

The substance can be absorbed into the body by inhalation.|inhalation, skin and/or eye contact (liquid)

dizziness; cardiac arrhythmias; liquid: frostbite

Dizziness. Headache. Unconsciousness.

ON CONTACT WITH LIQUID: FROSTBITE.

Redness. See Skin.

central nervous system, heart

Methane, bromotrifluoro-: ACTIVE|Use of Halon 1301 suppression of methane explosion in coal mine is discussed.|THE BROMINE-CONTAINING FLUOROCARBONS OPERATE BY CHEMICAL INTERRUPTION OF THE COMBUSTION CHAIN, AND ARE USED IN TOTAL FLOODING SYSTEMS FOR COMPUTER ROOMS AND TELEPHONE FACILITIES, AS WELL AS AIRCRAFT AND PORTABLE FIRE EXTINGUISHERS, INCLUDING USE ON THE AIR FORCE P-13 RAPID INTERVENTION CRASH TRUCKS. HALON EMERGES FROM THE FIRE EXTINGUISHER NOZZLE AS A MIXTURE OF 85 PERCENT LIQUID AND 15 PERCENT VAPOR AND IS DISCHARGED OVER LONG DISTANCES. IT COMPLETELY VAPORIZES UPON CONTACT WITH FIRE. /BROMINATED FLUOROCARBONS/|The production of bromotrifluoromethane has to be stopped in accordance with the Montreal Protocol of 1987 as it plays an important role in the destruction of the earth's ozone layer. The Montreal Protocol stipulates that the production and consumption of compounds that deplete ozone in the stratosphere including halons, are to be phased out by 2000.

Gas chromatographic determination of bromotrifluoromethane pollutant in air samples is discussed.|NIOSH Method: 1017. Analyte: Bromotrifluoromethane. Matrix: Air. Procedure: Gas chromatography, flame ionization detector. For bromotrifluoromethane this method has an estimated detection limit of 0.05 mg/sample. The precision/RSD is 0.038 @ 3 to 12 mg/sample and the recovery is 100%. Applicability: The working range is 330 to 3000 ppm (2000 to 18,000 mg/cu m) for a 1 liter air sample. Interferences: None reported.|GAS CHROMATOGRAPHIC METHOD FOR DETERMINING FLUOROCARBONS IN AIR IS DESCRIBED. CONCN IN AIR ARE DETERMINED DIRECTLY. /FLUOROCARBONS/|A GAS CHROMATOGRAPHIC PROCEDURE FOR DETERMINING ATMOSPHERIC LEVELS OF FLUOROCARBONS IS DESCRIBED. COLUMN IS TEMP PROGRAMMED TO SEPARATE HALOGENATED COMPONENTS WHILE MAINTAINING SHORT RETENTION TIMES FOR EACH COMPONENT. FREON 113 INCL. /FLUOROCARBONS/|For more Analytic Laboratory Methods (Complete) data for BROMOTRIFLUOROMETHANE (6 total), please visit the HSDB record page.

GAS CHROMATOGRAPHIC METHOD FOR DETERMINING FLUOROCARBONS IS DESCRIBED. CONCN IN BODY FLUIDS ARE DETERMINED BY MEANS OF HEAD SPACE ANALYSIS. /FLUOROCARBONS/|HEXANE EXTRACTION PROCEDURE FOR THE DETERMINATION OF COMMON FLUOROCARBON PROPELLANTS IN BLOOD WAS EVALUATED. AN ANALYSIS OF SAMPLE HEADSPACE WAS ALSO EVALUATED FOR DETERMINING CHLOROPENTAFLUOROETHANE IN BLOOD. BOTH PROCEDURES INVOLVED ANALYSIS BY GAS CHROMATOGRAPHY USING ELECTRON CAPTURE DETECTION. THE WIDELY USED HEXANE EXTRACTION PROCEDURE FOR DETERMINING PPM LEVELS OF VOLATILE HALOCARBONS IN TISSUE WAS EVALUATED BY A COMBINATION OF RADIOCHEMICAL AND GAS CHROMATOGRAPHIC TECHNIQUES. THE DATA SUGGEST THAT HEXANE EXTRACTION GIVES SIGNIFICANTLY LOW RESULTS. /FLUOROCARBONS/|FLUOROCARBON DETERMINATION IN BLOOD: GAS CHROMATOGRAPHY WITH ELECTRON CAPTURE DETECTION. /FLUOROCARBONS/