Chlorotrifluoromethane

104.46

104.46

200-894-4

7C6U91JNED

0420

1022

DTXSID4052500

Colorless gas

2903772016

0

1.65

Chlorotrifluoromethane is a colorless odorless gas. It is shipped as a liquefied gas under its own vapor pressure. It is noncombustible. It can asphyxiate by the displacement of air. Contact with the liquid can cause frostbite. Exposure of the container to prolonged heat or fire may cause it to rupture violently and rocket.

1.3 g/cm³

-181 °C

-81.4 °C @ Press: 760 Torr

1.261

Solubility in water: none

-70°C

21,400 mm Hg @ 25 deg C

Relative vapour density (air = 1): 3.6

Reference value Inhalation-Rat LC50: 35000 PPM/ 15 points

Non-combustible at normal temperature; flammable with high heat; combustion produces toxic fluoride and chloride gases

Ethereal

7.00e-16 cm3/molecule*sec

1.38 atm-m3/mole|Henry's Law constant = 1.38 atm-cu m/mol @ 25 °C

Heavier than air|vapor pressure = 1 mm HG @ -149.5 °C; 10 mm HG @ -134.1 °C; 40 mm HG @ -121.9 °C; 100 mm HG @ -111.7 °C; 400 mm HG @ -92.7 °C|Hydroxyl radical rate constant = 7.0X10-16 cu m/molc-sec @ 25 °C|Dielectric constant (liquid): 2.3 at -30 °C; (vapor): 1.0013 at 29 °C

No rapid reaction with air. No rapid reaction with water.

Fluorinated Organic Compounds

The reaction of aluminum with various halogenated hydrocarbons produces a self-sustaining reaction with sufficient heat to melt aluminum pieces, examples of other halogenated hydrocarbons are fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane. The vigor of the reaction appears to be dependent on the combined degree of fluorination and the vapor pressure, [Chem. Eng. News 39(27):44(1961)].

The gas is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen.

3996.3 gcal/gmol

Critical temperature: 28.8 °C; Critical pressure: 3.86 MPa

2.2

1022

3

20-59

23-36/37/39-59

N

The warehouse is ventilated, low temperature and dry; lightly loaded and unloaded; stored separately from flammable materials

High heat and explosive

P41, P403

H280

Special Hazards of Combustion Products: Toxic fumes of Cl and F (USCG, 1999)|Not combustible. Heating will cause rise in pressure with risk of bursting.

|Warning|H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P410+P403, and P502|Aggregated GHS information provided by 112 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P410+P40, and 410+P403

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2016)

Approved respirator, safety goggles, rubber gloves, safety shoes. (USCG, 1999)

Nonflammable.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

SUFFICIENT EXHAUST & GENERAL VENTILATION SHOULD BE PROVIDED TO KEEP VAPOR CONCN BELOW RECOMMENDED LEVELS. /FLUOROCARBONS/|If material not involved in fire: Attempt to stop leak if without undue personnel hazard.|Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment.

/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Fire or Explosion: Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.|/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.|/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for CHLOROTRIFLUOROMETHANE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Slightly irritant.

Personal protection: self-contained breathing apparatus. Ventilation. NEVER direct water jet on liquid. Do NOT let this chemical enter the environment.

Fireproof if in building.

On loss of containment this substance can cause suffocation by lowering the oxygen content of the air in confined areas.

Exposure could cause narcotic effects. Exposure at high concentrations could cause asphyxiation. The substance may cause effects on the cardiovascular system. This may result in impaired functions.

NO contact with hot surfaces. See Chemical Dangers.

Use ventilation, local exhaust or breathing protection.

Cold-insulating gloves.

Wear safety goggles, face shield or eye protection in combination with breathing protection.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chlorotrifluoromethane is produced, as an intermediate or a final product, by process units covered under this subpart.

Chlorotrifluoromethane was detected in the troposphere above the Antarctic region at concentrations of 3.6 and 3.2 parts per trillion, with an average global concentration estimated as 4.0 parts per trillion(1). Chlorotrifluoromethane was detected at a concentrations of 3.9 parts per trillion (14.4 kilometers above the earth's surface) and 2.3 parts per trillion (33.2 kilometers above the earth's surface)(2).|Trace gases have been measured, by electron-capture gas chromatography and gas chromatography-mass spectrometry, at the South Pole (SP) in Antarctica and in the US Pacific Northwest (PNW) (aprox 45 deg N) during Jan of each year 1975-80. The concn of chlorotrifluoromethane increased at a rate of 12%/yr at the SP and 8%/yr in the PNW.

practically nontoxic

Chlorotrifluoromethane's production and use as a refrigerant or as an azeotrope with CHF3 for very low temperature applications(1) may lead to its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 188(SRC), determined from a measured log Kow of 1.65(2) and a recommended regression-derived equation(3), indicates that chlorotrifluoromethane is expected to have moderate mobility in soil(SRC). Volatilization of chlorotrifluoromethane is expected from moist soil surfaces(SRC) given a measured Henry's Law constant of 1.38 atm-cu m/mole(4). Chlorotrifluoromethane is expected to volatilize rapidly from dry soil surfaces based on a vapor pressure of 2.14X10+4 mm Hg(SRC) at 25 °C(5). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(6).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 188(SRC), determined from a measured log Kow of 1.65(2) and a recommended regression-derived equation(3), indicates that chlorotrifluoromethane is not expected to adsorb to suspended solids and sediment in water(SRC). Chlorotrifluoromethane is expected to volatilize rapidly from water surfaces(3) based on a measured Henry's Law constant of 1.38 atm-cu m/mole(4). Estimated half-lives for a model river and model lake are 3 and 97 hours, respectively(SRC). According to a classification scheme(5), an estimated BCF value of 10(3,SRC), from the measured log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(6).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), chlorotrifluoromethane, which has a measured vapor pressure of 2.14X10+4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase chlorotrifluoromethane is slowly degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 62 years(3,SRC). This compound will gradually diffuse into the stratosphere above the ozone layer where it will slowly degrade due to direct photolysis from UV-C radiation and contribute to the catalytic removal of stratospheric ozone(4,SRC). The half-life for this reaction has been estimated to range from 180 to 450 years(4).

The rate constant for the vapor-phase reaction of chlorotrifluoromethane with photochemically-produced hydroxyl radicals has been measured as 7.0X10-16 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 62 years at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Chlorotrifluoromethane is not expected to undergo hydrolysis or direct photolysis in the troposphere due to the lack of functional groups to hydrolyze or photodegrade due to lack of absorption of light at environmentally significant wavelengths. This compound will gradually diffuse into the stratosphere above the ozone layer where it will slowly degrade due to direct photolysis from UV-C radiation and contribute to the catalytic removal of stratospheric ozone(2,SRC). The half-life for this reaction has been estimated to range from 180 to 450 years(2).

An estimated BCF value of 10 was calculated for chlorotrifluoromethane(SRC), using a measured log Kow of 1.65(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of chlorotrifluoromethane is estimated as approximately 188(SRC), using a measured log Kow of 1.65(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that chlorotrifluoromethane is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for chlorotrifluoromethane was measured as 1.38 atm-cu m/mole(1). This value indicates that chlorotrifluoromethane will volatilize rapidly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 3 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 97 hours(2,SRC). Chlorotrifluoromethane's Henry's Law constant(1) indicates that volatilization from moist soil surfaces is expected to occur(SRC). Chlorotrifluoromethane is expected to volatilize rapidly from dry soil surfaces based on the measured vapor pressure of 2.14X10+4 mm Hg at 25 °C(3).

Chlorotrifluoromethane was identified, not quantified, in 4 of 8 human milk samples obtained from Bayonne, NJ; Pittsburgh, PA; Jersey City, NJ and Baton Rouge, LA(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,204 workers (188 of these are female) are potentially exposed to chlorotrifluoromethane in the US(1). Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where chlorotrifluoromethane is produced or used(SRC). The general population will be exposed to chlorotrifluoromethane via inhalation of ambient air(SRC).

...MAIN FACTOR AFFECTING FATE OF FLUOROCARBONS IS BODY FAT, WHERE THEY ARE CONCENTRATED & SLOWLY RELEASED INTO BLOOD AT CONCN THAT SHOULD NOT CAUSE ANY RISK OF CARDIAC SENSITIZATION. /FLUOROCARBONS/

Exposure may cause nausea, dizziness, and headache, and rapid suffocation. Contact with skin may cause frostbite. (USCG, 1999)

INHALATION: Remove to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen. SKIN: Wash affected areas with warm water. DO NOT USE HOT WATER. (USCG, 1999)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. /Chlorinated fluorocarbons/|For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations as needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Minimize physical activity and provide a quiet atmosphere. Monitor for pulmonary edema and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. Rinse mouth and administer 5 ml/kg up to 200 ml of water or dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... Treat frostbite with rapid rewarming techniques ... . /Chlorinated fluorocarbons/

EARLY...HUMAN EXPERIENCE INDICATED THAT HIGH VAPOR CONCN (EG, 20%) MAY CAUSE CONFUSION, PULMONARY IRRITATION, TREMORS & RARELY COMA, BUT THAT THESE EFFECTS WERE GENERALLY TRANSIENT & WITHOUT LATE SEQUELAE. ...CAUSE OF DEATH /FROM ABUSE OF FLUOROCARBONS/ IS IN CONSIDERABLE DOUBT... FREEZING OF AIRWAY SOFT TISSUES CAN PROBABLY BE ELIMINATED AS A CAUSE OF DEATH EXCEPT IN CASES WHERE THE PRODUCT WAS SPRAYED DIRECTLY INTO THE MOUTH FROM ITS CONTAINER OR FROM A BALLOON CONTAINING SOME LIQUID. LARYNGEAL SPASM OR EDEMA, OXYGEN DISPLACEMENT, OR SENSITIZATION OF MYOCARDIUM ENDOGENOUS CATECHOLAMINES WITH SUBSEQUENT VENTRICULAR FIBRILLATION APPEAR TO BE REASONABLE POSSIBILITIES. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/|EXCESSIVE SKIN CONTACT WITH LIQUID FLUOROCARBONS SHOULD BE MINIMIZED TO PREVENT DEFATTING OF SKIN... /FLUOROCARBONS/|A SPECIAL CLASS OF CHEMICALS SUBJECT TO ABUSE BY INHALATION ARE THE FLUOROHYDROCARBONS... THE "SNIFFING" OF SUCH AEROSOL SPRAYS IS HAZARDOUS PRACTICE. ...110 "SUDDEN SNIFFING DEATHS" /HAVE BEEN IDENTIFIED/... IN EACH CASE THE VICTIM SPRAYED THE AEROSOL INTO A PLASTIC BAG, INHALED THE CONTENTS, BECAME EXCITED, RAN 90 M OR SO, COLLAPSED, & DIED. NECROPSY FINDINGS WERE LARGELY NEGATIVE... ALTHOUGH AMOUNT OF PROPELLANT ABSORBED INTO BLOOD FROM USE OF HAIRSPRAY, COSMETIC, HOUSEHOLD, & MEDICATED AEROSOLS MUST VARY WITH CIRCUMSTANCES, PHYSICIAN IS ADVISED TO COUNSEL...PATIENT ON POTENTIAL DANGERS, PARTICULARLY FROM THEIR USE IN POORLY VENTILATED CONFINED AREAS. IT IS POSSIBLE THAT PATIENTS WITH CARDIAC OR RESPIRATORY DISORDERS MAY PROVE ESPECIALLY SUSCEPTIBLE. /FLUOROHYDROCARBONS/|BECAUSE OF DECREASED USE IN CONSUMER PRODUCTS, ABUSE HAS BEEN ELIMINATED.|For more Human Toxicity Excerpts (Complete) data for CHLOROTRIFLUOROMETHANE (7 total), please visit the HSDB record page.

The substance can be absorbed into the body by inhalation.

Confusion. Dizziness. Headache. Unconsciousness.

ON CONTACT WITH LIQUID: FROSTBITE.

See Skin.

CFC-13 ... IS /PRIMARILY USED/ AS A SPECIALTY LOW TEMPERATURE REFRIGERANT (1984)|REFRIGERANTS, 39%; FOAM BLOWING AGENTS, 17%; SOLVENTS, 14%; FLUOROPOLYMERS, 14%; STERILANT GAS, 2%; AEROSOL PROPELLANTS, 2%; FOOD FREEZANT, 1%; OTHER, 8%; EXPORTS, 3% (1985) /FLUOROCARBONS/

Grade: 99.0% minimum purity

Methane, chlorotrifluoro-: ACTIVE

Concn of approx 4 ppt were measured in air using gas chromatography/mass spectroscopy.|Trace gases have been measured, by electron-capture gas chromatography and gas chromatography-mass spectrometry.