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1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine

1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine structure

CAS No:
738-99-8
Formula:
C12H24N6O2P2
Chemical Name:
1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine
Synonyms:
Piperazine,1,4-bis[bis(1-aziridinyl)phosphinyl]-;Phosphine oxide,1,4-piperazinediylbis[bis(1-aziridinyl)-;1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine;1,4-Bis(N,N′-diethylene phosphamide)piperazine;Dipin;Dipine;1,4-Piperazinediylbis[bis(1-aziridinyl)phosphine oxide];NSC 80096;1,4-Bis-(bis-aziridin-1-yl-phosphinoyl)-piperazine;1,4-Bis[bis(aziridin-1-yl)phosphoryl]piperazine

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1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine Basic Attributes

Molecular Weight：

346.31

Exact Mass：

346.31

UNII：

L16KNK08VM

NSC Number：

80096

DSSTox ID：

DTXSID50224219

Characteristics

PSA：

52.7

XLogP3：

-1.2

Melting Point：

186 °C

Toxicity：

Peritoneal-mouse LD50: 90 mg/kg; oral-mouse LD50: 68 mg/kg

Flammability characteristics：

Combustible; burning produces toxic nitrogen oxides, phosphorus oxide fumes

Safety Information

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) (See all compounds classified as Antineoplastic Agents, Alkylating.)|Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)|Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)

MeSH Entry Terms：

dipin

Computed Properties

Molecular Weight:346.31
XLogP3:-1.2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:346.14359802
Monoisotopic Mass:346.14359802
Topological Polar Surface Area:52.7
Heavy Atom Count:22
Complexity:482
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine

Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Computed Properties

1,4-Bis[bis(1-aziridinyl)phosphinyl]piperazine

SDS

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