Acid Green 5

792.85

792.122192

5717828

219-091-5

3F7BHA64Z0

DTXSID8020672

Deep-purple powder|Reddish-brown powder

32041200

202.99000

8.26930

Red to Dark Purple Solid

290 °C (dec.)(lit.)

H2O: soluble1mg/mL

Store at RT.

2.97X10-42 mm Hg at 25 deg C (est)

LD50 orally in rats: >2 g/kg (Lu, Lavalle)

Henry's Law constant = 1.4X10-36 atm-cu m/mol at 25 °C (est)

Hydroxyl radical reaction rate constant = 4.1X10-10 cu cm/molec-sec at 25 °C (est)

NONH for all modes of transport

2

68

36/37-24/25

BQ4900000

Xn

P201, P202, P281, P308+P313, P405, P501

H351

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Certificates issued for the following color additives and all mixtures containing these color additives are canceled and have no effect after October 4, 1966, and use of such color additives in the manufacture of foods, drugs, or cosmetics after that date will result in adulteration: FD&C Green No. 2 is included on this list.

|Warning|H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 7 companies from 3 notifications to the ECHA C&L Inventory.

LD50 Rat oral >2.0 g/kg bw|LD50 Mouse sc 525 mg/kg bw|LD50 Mouse iv 700 mg/kg

FD&C Green No. 2's production and use as a dye(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Acid dyes, such as FD&C Green No. 2, typically exhibit very low solubilities in octanol and have water solubilities that exceed 100 g/L. Therefore, these compounds would be expected to remain in the water column in the aquatic environment and show little affinity for organic matter(1) which suggests a potential to leach in soil(SRC). Volatilization of FD&C Green No. 2 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-36 atm-cu m/mole(SRC), using a fragment constant estimation method(2). FD&C Green No. 2 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.97X10-42 mm Hg at 25 °C(SRC), determined from a fragment constant method(2).|AQUATIC FATE: Acid dyes, such as FD&C Green No. 2, typically exhibit very low solubilities in octanol and have water solubilities that exceed 100 g/L. Therefore, these compounds would be expected to remain in the water column in the aquatic environment and show little affinity for organic matter(1). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 1.4X10-36 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of 0.82(5) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), FD&C Green No. 2, which has an estimated vapor pressure of 2.97X10-42 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase FD&C Green No. 2 may be removed from the air by wet or dry deposition(SRC). FD&C Green No. 2 absorbs light at wavelengths of 630 nm(4), and therefore may be susceptible to direct photolysis by sunlight(SRC).

Acid dyes, such as FD&C Green No. 2, readily dissociate in water(1). FD&C Green No. 2 absorbs light at wavelengths of 630 nm(2), and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for FD&C Green No. 2(SRC), using an estimated log Kow of -2.74(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Acid dyes, such as FD&C Green No. 2, typically exhibit very low solubilities in octanol and have water solubilities that exceed 100 g/L. Therefore, these compounds would be expected to remain in the water column in the aquatic environment and show little affinity for organic matter(1).

The Henry's Law constant for FD&C Green No. 2 is estimated as 1.4X10-36 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that FD&C Green No. 2 is expected to be essentially nonvolatile from water surfaces(2). FD&C Green No. 2's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected occur(SRC). FD&C Green No. 2 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.97X10-42 mm Hg(SRC), determined from a fragment constant method(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 18,350 workers (7,859 of these were female) were potentially exposed to FD&C Green No. 2 sodium in the US(1). Occupational exposure to FD&C Green No. 2 may occur through dermal contact with this compound at workplaces where FD&C Green No. 2 is produced or used(SRC).

Light green SF exhibits high plasma binding.|Studies in rats and dog involving oral administration of light green SF indicate that only small amounts of the dye (<5%) are absorbed and excreted, mainly in the feces. Following its iv injection in rats, about 20% of the dye was excreted in the bile within four hours.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

acid green 5

Benzenemethanaminium, N-ethyl-N-[4-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl](4-sulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-3-sulfo-, inner salt, sodium salt (1:2): ACTIVE|Certification of Light Green SF for use as a color additive in foods, drugs or cosmetics was cancelled in the US in 1966 and in Japan in 1970. Light Green SF is not included in the list of colorants permitted for use in food in the European Economic Communities ...|Color additives were initially regulated in the United States under the U.S. Department of Agriculture's (USDA) Bureau of Chemistry. In 1906, the Food and Drugs Act was passed by Congress, which prohibited the use of poisonous or deleterious colors in confectionery and the coloring or staining of food to conceal damage or inferiority. In 1927, responsibility of the Food and Drugs Act was transferred to FDA. Increasing government oversight, the Federal Food, Drug, and Cosmetic Act (FFDCA) was passed in 1938 and established the three following categories for colors: FD&C: colors used in foods, drugs and cosmetics; D&C: colors used in drugs and cosmetics when in contact with mucous membranes or ingested; and Ext. D&C: colors used in products applied externally.|Light Green SF has not been produced commercially in Japan since its use as a food color was forbidden in 1970.

Food Additives -> COLOUR;