2′,4′-Dichloro-5′-fluoroacetophenone
-
2′,4′-Dichloro-5′-fluoroacetophenone
structure -
-
CAS No:
704-10-9
-
Formula:
C8H5Cl2FO
-
Chemical Name:
2′,4′-Dichloro-5′-fluoroacetophenone
-
Synonyms:
Ethanone,1-(2,4-dichloro-5-fluorophenyl)-;Acetophenone,2′,4′-dichloro-5′-fluoro-;1-(2,4-Dichloro-5-fluorophenyl)ethanone;2′,4′-Dichloro-5′-fluoroacetophenone;1-(2,4-Dichloro-5-fluorophenyl)ethan-1-one
- Categories:
-
CAS No:
2′,4′-Dichloro-5′-fluoroacetophenone Basic Attributes
207.02900
207.03
615-113-6
DTXSID80220668
2914700090
Characteristics
17.07000
3
White to pale-yellow Crystal
1.425
35-36 °C
112-115 °C @ Press: 5 Torr
>110ºC
1.546
Safety Information
NONH for all modes of transport
3
R36/37/38
S26-S36
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2′,4′-Dichloro-5′-fluoroacetophenone Use and Manufacturing
In a 10001111 four-necked flask, 2, 4-dichlorofluorobenzene was charged15 (^ (0.911111), cooling to 20 ° (: adding aluminum chloride 200. 2g (l.5mol), in the 20 ~ 30 ° CAdd acetyl chloride 78. 5g (l. Omol), 2 ~ 3h plus finished.Slowly heat up to 40 ° C and incubate for 30 min, then slowly heat up to 70 ° C and incubate for 1 ~ 2h, then slowly heat up to 110 ° C, 110 ± 2 ° CHeat 3 ~ 4h, cooling, add 500g 5percent hydrochloric acid, hydrolysis at 80 ~ 90 ° C 2 ~ 3h, after washing to neutral, there areThe phase of the product was recrystallized from the second distillation to obtain 168 g of 2, 4-dichloro-5-fluoroacetophenone in an amount of 99.8percent. The yield was 89.3percentTo a warm solution of 1, 3-dichloro-4-fluorobenzene at 70° C. (175.0 gm), anhydrous aluminum chloride was added in small portion with stirring (260.0 g). Then acetic anhydride was added in small portion with stirring (125 mL) followed by an additional amount of aluminum chloride (159.0 g). The temperature was slowly raised to 120° C. with stirring for 25 hours. The thick reaction mixture was cooled and poured into 400 cc of concentrated hydrochloric acid containing ice. The oil was extracted with methylene chloride, washed with water, dried over anhydrous magnesium sulfate and concentrated to give 165.0 g of oil (2).
Used as a pharmaceutical intermediate, it is the third-generation broad-spectrum high-efficiency quinolone antibacterial agent ciprofloxacin; the main intermediate of anthoxacin
Computed Properties
Molecular Weight:207.03
XLogP3:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:205.9701483
Monoisotopic Mass:205.9701483
Topological Polar Surface Area:17.1
Heavy Atom Count:12
Complexity:186
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2′,4′-Dichloro-5′-fluoroacetophenone
-
InquiryCAS No.: 704-10-9Grade: Pharmaceutical GradeContent: 99%
-
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 704-10-9Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
10 YRS
Business licensed Certified factoryManufactory SupplierInquiryCAS No.: 704-10-9Grade: Pharmaceutical GradeContent: 99.5% -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Pharmaceutical intermedaite,Agricultural chemical intermediateInquiryCAS No.: 704-10-9Grade: Pharmaceutical GradeContent: 99.5% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 704-10-9Grade: Industrial GradeContent: 99%
Learn More Other Chemicals
-
Trifluoromethanol
1493-11-4
-
N-(2-BROMO-4,5-DIFLUOROPHENYL)ACETAMIDE
64695-81-4
-
4-Nitro-m-phenylenediamine
5131-58-8
-
4-Hydroxy-3,5-dimethoxybenzamide Formula
3086-72-4
-
2-(3,4-dimethoxy-2-methylphenyl)ethanamine Formula
77200-86-3
-
1,11-Dihydroxydodecamethylhexasiloxane Formula
4029-00-9
-
β-Methyl-δ-valerolactone Structure
1121-84-2
-
8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE Structure
131190-82-4
-
What is (R)-5-(chloromethyl)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)oxazolidin-2-one
1239662-46-4
-
What is 2-(3-aminophenyl)-1-morpholin-4-ylethanethione
5425-46-7
2′,4′-Dichloro-5′-fluoroacetophenone
SDSRequest for Quotation