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Melatonin

Melatonin structure

CAS No:
73-31-4
Formula:
C13H16N2O2
Chemical Name:
Melatonin
Synonyms:
Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-;Acetamide,N-[2-(5-methoxyindol-3-yl)ethyl]-;N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide;N-Acetyl-5-methoxytryptamine;Melatonin;Melatonine;5-Methoxy-N-acetyltryptamine;N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide;Regulin;Melovine;Circadin;Melatol;NSC 113928;NSC 56423;3-(2-Acetamidoethyl)-5-methoxyindole;Melaxen;Slenyto;942407-96-7;1581233-31-9
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

Description

Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties.

Melatonin Basic Attributes

Molecular Weight：

232.27800

Exact Mass：

232.28

EC Number：

200-797-7

HScode：

2932999099

Characteristics

PSA：

54.12000

XLogP3：

0.8

Appearance：

Solid

Density：

1.269 g/cm³

Melting Point：

117 °C

Boiling Point：

512.8ºC at 760 mmHg

Flash Point：

264ºC

Refractive Index：

1.6

Water Solubility：

>34.8 [ug/mL]

Storage Conditions：

-15ºC

Vapor Pressure：

1.4X10-7 mm Hg at 25 deg C (est)

Toxicity：

LD50 orally in Rabbit: > 3200 mg/kg

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R60

safety instructions：

S24/25

RTECS Number：

AC5955000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

Melatonin Use and Manufacturing

1. Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase
2. Sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger
3. Immunostimulant;Melatonin receptor ligand
4. Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

Computed Properties

Molecular Weight:232.28
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:232.121177757
Monoisotopic Mass:232.121177757
Topological Polar Surface Area:54.1
Heavy Atom Count:17
Complexity:270
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Methanol

Dimethyl sulfate

Drug Function and Efficacy

Regulate sleep

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Jin Aoli Melatonin Capsules

Asent Melatonin Capsules

Kerong Melatonin Capsules
Specifications	3 mg/tablet

See More Related Drugs

Registered Holders

SWATI SPENTOSE PRIVATE LTD

United States
Active
FLAMMA SPA

United States
Active
FLAMMA S.P.A.

Italy
Active

See More Registered Holders

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