(5-CHLORO-2-METHOXYPHENYL)ACETONITRILE

Compound Z-0-6 (32 g, 168 mmol) was dissolved in DMSO (200 mL)Sodium cyanide (29 g, 606 mmol) was added.The mixture was protected under nitrogen, Heated to 80 ° C for 3 h.The reaction mixture was cooled to room temperature, Add water to disperse, Suction filter.The filter cake is washed with a small amount of water.Dried to give an orange-red solid Z-0-7 (31 g, yield: 98.3percent).To a solution of 4-chloro-2-(chloromethyl)-1-methoxybenzene (12 g, 63.15 mmol) in DMSO (60 mL) was carefully added sodium cyanide (4.4 g, 95.6 mmol) at room temperature. To a solution of 4-chloro-2-(chloromethyl)-l-methoxybenzene (12g, 63.15mmol) in DMSO (60mL) was carefully added sodium cyanide (4.4g, 95.6mmol) at room temperature. Above reaction mixture was then heated at 100°C for 3 hours. After cooling to room temperature, the reaction mixture was poured in to cold water (200mL) to get precipitates. The precipitate thus formed were filtered off and dried under vacuo to afford lOg (yield, 87.46percent) of the desired compound as an off white solid. The material was used directly for the next step.Compound Z-0-7 (32 g, 177 mmol) was dissolved in methyl formate (400 mL)plusInsodium(8.14 g, 354 mmol).The mixture was protected under nitrogen, Heated to reflux for 24 hThe reaction mixture was cooled to room temperature, Add water to quench the reaction, Ethyl acetate extraction (400 x 2 mL), The combined organic phases were washed with water (200 x 2 mL), Dried over anhydrous sodium sulfate, A yellow solid, Z-0-8 (10.5 g, yield: 28.4percent) was obtained.

Molecular Weight:181.62
XLogP3:2.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:181.0294416
Monoisotopic Mass:181.0294416
Topological Polar Surface Area:33
Heavy Atom Count:12
Complexity:186
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes