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Home > Encyclopedia > n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride

n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride

n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride structure

n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride 

structure
  • CAS No:

    7084-11-9

  • Formula:

    C8H18ClN3

  • Chemical Name:

    n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride

  • Synonyms:

    1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE HYDRCHLORIDE;1-ETHYL-3-(3'-DIMETHYLAMINOPROPYL)CARBODIIMIDE, HCL;1-ETYHL-3(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE HYDROCHLORIDE;ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE HYDROCHLORIDE;EDAC, HYDROCHLORIDE;WATER SOLUBLE CARBODIIMIDE;WATER SOLUBLE CARBODIIMIDE HYDROCHLORIDE;1,3-Propanediamine, N-(ethylcarbonimidoyl)-N,N-dimethyl-, hydrochloride

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

Among the carbodiimides available, n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide (EDC) hydrochlorideis commonly used because it is available as an HCl salt, is easy to handle, and the urea by-product, N-(3-dimethylaminopropyl)-N' -ethylurea (EDU), is soluble in water and can easily be removed[1].

n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride Basic Attributes

191.7

191.118927

230-383-1

19W5TL0WJ4

97064

Characteristics

27.96000

1.93390

110-115 °C(lit.)

197.7ºC at 760 mmHg

73.4ºC

-20ºC

Inert atmosphere,Room Temperature

Safety Information

3

Xi

26-36/37/39

FF2200000

Xi: Irritant;

37/38-41

|Danger|H302 (49.7%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 258 companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride Use and Manufacturing

Uses

N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) is a carbodiimide coupling reagent commonly used for the preparation of amides from carboxylic acids and amines[1].

1,3-Propanediamine, N3-(ethylcarbonimidoyl)-N1,N1-dimethyl-, hydrochloride (1:1): ACTIVE

Computed Properties

Molecular Weight:191.70
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:191.1189253
Monoisotopic Mass:191.1189253
Topological Polar Surface Area:28
Heavy Atom Count:12
Complexity:134
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:No

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