4,6-DICHLORO-PYRIDIN-3-YLAMINE
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4,6-DICHLORO-PYRIDIN-3-YLAMINE
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CAS No:
7321-93-9
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Formula:
C5H4Cl2N2
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Chemical Name:
4,6-DICHLORO-PYRIDIN-3-YLAMINE
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Synonyms:
4,6-DICHLOROPYRIDIN-3-AMINE;4,6-Dichloro-3-pyridinamine;2,4-Dichloro-5-aMinopyridine;5-AMINO-2,4-DICHLOROPYRIDINE;3-Pyridinamine, 4,6-dichloro-;4,6-DICHLORO-PYRIDIN-3-YLAMINE;5-Amino-2,4-dichloropyridine 97+%;Pyridine,5-amino-2,4-dichloro- (7CI,8CI)
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CAS No:
Characteristics
38.9
1.8
1.5±0.1 g/cm3
80-81 °C(Solv: ligroine (8032-32-4))
290.8°C at 760 mmHg
129.7±25.9 °C
1.623
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4,6-DICHLORO-PYRIDIN-3-YLAMINE Use and Manufacturing
NaOH (6.60 g, 165 mmol) was dissolved in HB. 4, 6-Dichloro-3-pyridinamine STR366 To a solution of 172A (192 mg, 1.0 mmol) in 1.0 mL of dry DMF cooled at 0° C. was added triethylamine (0.14 mL, 1.0 mmol), followed by diphenylphosphoryl azide (0.216 mL, 1.0 mL). The mixture was stirred at ambient temperature for 1.0 hr and poured into a mixture of ice-water-EtOAc. The reaction mixture was extracted with EtOAc (x2) and combined extracts washed with water, sat'd NaHCO3, sat'd NaCl and dried over Na2 SO4. Concentration in vacuo gave 217 mg of light tan solid. Above solid was dissolved in 2.5 mL of dry toluene and heated to reflux. A solution of tert-butyl alcohol in 1.0 mL of dry toluene was added and the mixture was heated at 90-95° C. for 4.0 hrs. Concentration in vacuo followed by flash chromatography (hexane-EtOAc: 95:5) on silica gel gave 168 mg of colorless oil. Above material was treated with trifluoroacetic acid (1.5 mL) and CH2 Cl2 (0.5 mL). Concentrated in vacuo and residue was extracted with CH2 Cl2 (x2) and combined extracts washed with water, sat'd NaHCO3, sat'd NaCl and dried over Na2 SO4. Concentration in vacuo gave 104 mg of 172B as a white solid.
Computed Properties
Molecular Weight:163.00
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:161.9751535
Monoisotopic Mass:161.9751535
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:99
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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