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Talopram

Talopram structure

CAS No:
7182-51-6
Formula:
C20H25NO
Chemical Name:
Talopram
Synonyms:
1-Isobenzofuranpropanamine,1,3-dihydro-N,3,3-trimethyl-1-phenyl-;1-Phthalanpropylamine,N,3,3-trimethyl-1-phenyl-;1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine;Lu 3-010;1-Phenyl-1-(3-methylaminopropyl)-3,3-dimethylphthalane;N,3,3-Trimethyl-1-phenyl-1-phthalanpropylamine;3,3-Dimethyl-1-(methylaminopropyl)-1-phenylphthalane;3,3-Dimethyl-1-(3-methylaminopropyl)-1-phenylphthalan;Talopram;Phthalapromine;26928-36-9
Categories:
Organic Chemistry > Amides

Description

Talopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed.

Talopram Basic Attributes

Molecular Weight：

295.426

Exact Mass：

295.42

NSC Number：

104350

Characteristics

PSA：

21.3

XLogP3：

3.5

Density：

1.018g/cm3

Boiling Point：

403.1ºC at 760 mmHg

Flash Point：

175.3ºC

Refractive Index：

1.542

Drug Information

MeSH Entry Terms：

(11C)talopram

Computed Properties

Molecular Weight:295.4
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:295.193614421
Monoisotopic Mass:295.193614421
Topological Polar Surface Area:21.3
Heavy Atom Count:22
Complexity:361
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes